1(a). Section 7.1.1(a) of the Credit Agreement is hereby amended by replacing each instance of the word “consolidated” with the word “consolidating.”
1(a). An employee, when advanced from one title to another, shall move up one step in the current range and be placed on the step of the new range that is equal thereto in salary, or if no step is equal in salary, on the next higher step.
1(a). Section 2.1(a) of the Credit Agreement is hereby amended and restated to read as follows:
1(a). Agreed – August 23/22
1(a). Section 6.1(a) of the Agreement is hereby amended by adding the following to the end of such section: Without limitation of the foregoing, each of the Company, Parent and Purchaser shall use its reasonable best efforts to (i) make or cause to be made the applications or filings required to be made, if any, by Parent, Purchaser, or the Company or any of the Acquired Companies under or with respect to the Xxxx-Xxxxx-Xxxxxx Antitrust Improvements Act of 1976 (the “HSR Act”) or any other applicable Legal Requirement for any domestic or foreign jurisdiction in connection with the authorization, execution and delivery of this Agreement and the consummation of the Transactions, and pay any fees due in connection with such applications or filings, as promptly as is reasonably practicable, and (ii) reasonably comply at the earliest practicable date with any request under or with respect to the HSR Act and any such other applicable Legal Requirement for additional information, documents or other materials received by Parent or the Company from the FTC or the DOJ or any other Governmental Body in connection with such applications or filings or the Transactions. Each of the Company and Parent shall, and shall cause their respective Affiliates and Representatives to, furnish to the other all information necessary for any such application or other filing to be made in connection with the Transactions. If necessary to obtain from any Governmental Body any consents, licenses, permits, waivers, clearances, approvals, authorizations or orders required to be obtained or made by Parent or the Company or any of the Acquired Companies, under the HSR Act or otherwise, each of Parent and the Company shall cooperate with each other, and use its reasonable best efforts to resolve such objections as may be asserted by any Governmental Body. Notwithstanding anything to the contrary in this Agreement, in connection with any filing or submission required or action to be taken by either Parent and Purchaser, on the one hand, or the Company or any Acquired Company, on the other hand, to consummate the Transactions, in no event shall Parent, Purchaser, the Company or the Acquired Companies, or any of their respective Subsidiaries or Affiliates, be obligated to (1) propose or agree to make any sale, lease, license, transfer, conveyance, separate holding, disposal, divestiture, disposition or other encumbrance or any agreement to do any of the foregoing with respect to such asset or busines...
1(a). Section 2.1(a) of the Business Financing Agreement is hereby amended by deleting it in its entirety and replacing it with the following:
1(a). There was a common decrease in the downregulated genes among all but one of the post-ADT RP samples, though the degree of repression was strikingly more pronounced in one group. One RP sample clustered closely with the pre-ADT samples mainly due to relatively higher expression of downregulated, discriminating it from the rest of the post-ADT RP samples. The upregulated genes further segregated the post-ADT samples based on increased expression in one subgroup (high impact group) but relatively unchanged expression after ADT in the other subgroup (low impact group). Principal component analysis (PCA) of differentially expressed genes confirmed the observations of the hierarchical clustering. PCA revealed three distinct groups of samples, the high impact group, low impact group and pre-ADT Bx group. Three outlier RP samples did not cluster with any group, and one RP sample closely segregated with the pre-ADT Bx (Figure 3.1B). Although there was no significant difference in ADT exposure time in the high and low impact group, we observed striking differences in transcriptional signatures after ADT. For example, KLK3 (Prostate Specific Antigen or PSA) gene expression was more significantly decreased in the high impact group than in the low impact group after ADT (p < 2.14 x 10-3 Xxxx-Xxxxxxx test), concordant with the IPA results suggesting an decrease in androgen driven genes (Figure 3.1C). To biologically characterize the transcriptional changes specific to the low and high impact groups, we employed a subtyping method developed by You et al 218 that is associated with good and poor outcomes. Briefly, these subtypes utilize gene signatures to segregate patients into three groups, prostate cancer subtype 1, 2 or 3 (PCS1-3). The PCS1 subtype is enriched for genes involved in androgen receptor variant (AR-V) (ligand-independent, constitutively active) activation, and is associated with a poor prognosis. The PCS2 subtype is enriched for genes indicative of AR activation, and has a variable prognosis. PCS3 subtype is characterized by low activation of AR or AR-V associated genes (AR-suppressed), and has a variable prognosis.
1(a). Section 6.1(a) of the Agreement shall be amended, effective as of the closing of the issuance and sale to TW of the TW Subscription Shares, by being replaced in its entirety with the following:
1(a). The Parties agree that the inventory already recorded in the 2014 Italian GAAP Financial Statements - prepared pursuant to Section 5.3 - which is still physically exiting at Closing Date will have the same value indicated in the 2014 Italian GAAP Financial Statements and the new inventory will be valued by applying the same Italian GAAP principles used for the preparation of the 2014 Italian GAAP Financial Statements.
1(a). Section 2.1(a) of the SAPA is hereby amended and restated in its entirety as follows:
