Aortic Pulse Wave Velocity Sample Clauses

Aortic Pulse Wave Velocity. Arterial walls stiffen with age and the primary structural change with ageing is medial degeneration, which leads to progressive stiffening of the large elastic arteries [325]. The media of large arteries is composed of VSMC’s and elastic and collagen fibres, comprising functional musculoelastic sheets [326]. Arterial pulsation has a direct effect on collagen and elastin in the arterial wall, disrupting muscular attachments and causing elastin fibres to fatigue and fracture [325]. Another major change in the arterial wall is that of calcium deposition; the calcium content of the arterial wall increases with age, particularly after the fifth decade, which also contributes to arterial stiffness [327]. A well- validated method for the assessment of arterial stiffness is pulse wave velocity (PWV) [328, 329]. Increased PWV is related in part to the extent of calcium within the artery and is a simple, non-invasive, radiation free method for estimating VC. Pulse wave velocity can be measured in any arterial segment between two regions with carotid-femoral PWV is the most widely used method for assessing central arterial or aortic stiffness [330] which is shown to be an independent predictor of CV mortality and morbidity in the elderly [331, 332], as well as in the general population [333, 334]. The assessment of aortic PWV involves the measurement of two quantities: the transit time of the arterial pulse along an arterial segment and the distance between both recording sites (Figure 1.11).
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