Caveolin-mediated endocytosis Sample Clauses

Caveolin-mediated endocytosis. Similar to the clathrin-coated vesicles, caveolae vesicles also originate from cholesterol-enriched invaginations of the plasma membrane. They invaginated as flask-shaped vesicles within the plane of the plasma membrane, or as detached vesicles. In addition, caveolae can fuse to form grape-like structures and tubules with sizes larger than 100 nm (Xxxxx, X.X. et al., 1999, Pelkmans, X. et al., 2001). Caveolae are mainly composed of cholesterol and sphingolipids and accumulate cholesterol binding-proteins known as caveolins, on the cytosolic face of the vesicles (Xxxxx, X.X. xx al., 1999, Xxxxxxx, X. et al., 2001, Xxxxxx, X. et al., 2002). Caveolae play a role in endocytosis of certain viruses such as simian virus 40 (SV40), as well as some bacteria and bacterial toxins such as cholera toxin (Khalil, I.A. et al., 2006) and like the clathrin pathway, calveolae require GTPases activity for the pinch off of vesicles. After internalisation, caveolae-derived vesicles fuse with caveosomes (Xxxxxxx, X.X. and X. Xxxxxxxxxx-Xxxxxxxx, 2001, Pelkmans, X. et al., 2002), which are pre- existing, stable, organelles with a neutral pH and it is believed that this uptake mechanism does not lead to lysosomal degradation (Xxxxxx, X.X., 2004). Macromolecules internalized via this route are transported to the endoplasmic reticulum (ER) (Pelkmans, X. et al., 2001) or to the trans-Golgi network (TGN) (Xxxxxx, X.X. and X. Xxxxxx, 2005) and therefore avoid lysosomal degradation. Due to its non-degradative nature (Ferrari, X. et al., 2003, Xxxxxx, X. et al., 2002), caveolar endocytosis represents an attractive pathway for gene delivery, even though this process is considered slow and has a small phase volume making it unlikely to be a primary uptake route. This uptake is also energy dependent so it can be inhibited by lowering temperature or by ATP depletion. In addition, drugs that specifically bind, sequester, or deplete cholesterol such as filipin, nystatin, and methyl-β-cyclodextrin, respectively, inhibit internalization by the caveolae (Lamaze, C. and X.X. Xxxxxx, 1995, Xxxxxxxxx, X.X. xx al., 1994). The caveloae pathway is actin-dependent and therefore drugs that affect the actin cytoskeleton such as cytochalasins are used to inhibit caveloae pathway without affecting the clathrin-mediated endocytosis, although these drugs do also inhibit macropinocytosis (Xxxxxx, X.X., 2004).
Sample 1Sample 2
AutoNDA by SimpleDocs

Related to Caveolin-mediated endocytosis

  • Vlastnictví Zdravotnické zařízení si ponechá a bude uchovávat Zdravotní záznamy. Zdravotnické zařízení a Zkoušející převedou na Zadavatele veškerá svá práva, nároky a tituly, včetně práv duševního vlastnictví k Důvěrným informacím (ve smyslu níže uvedeném) a k jakýmkoli jiným Studijním datům a údajům.

  • Rhytidectomy Scar revision, regardless of symptoms. • Sclerotherapy for spider veins. • Skin tag removal. • Subcutaneous injection of filling material. • Suction assisted Lipectomy. • Tattooing or tattoo removal except tattooing of the nipple/areola related to a mastectomy. • Treatment of vitiligo. • Standby services of an assistant surgeon or anesthesiologist. • Orthodontic services related to orthognathic surgery. • Cosmetic procedures when performed primarily: o to refine or reshape body structures or dental structures that are not functionally impaired; o to improve appearance or self-esteem; or o for other psychological, psychiatric or emotional reasons. • Drugs, biological products, hospital charges, pathology, radiology fees and charges for surgeons, assistant surgeons, attending physicians and any other incidental services, which are related to cosmetic surgery.

  • MSEA SEIU shall have exclusive rights to payroll deduction of membership dues, service fees, and premiums for current MSEA-SEIU spon- sored insurance programs. Deductions for other programs may be mutually agreed to by the parties.

  • Radiation Therapy/Chemotherapy Services This plan covers chemotherapy and radiation services. Respiratory Therapy This plan covers respiratory therapy services. When respiratory services are provided in your home, as part of a home care program, durable medical equipment, supplies, and oxygen are covered as a durable medical equipment service.

  • DUŠEVNÍ VLASTNICTVÍ The Institution acknowledges and agrees that the Sponsor shall have exclusive ownership rights to all Poskytovatel uznává a souhlasí, že Zadavatel bude mít výhradní vlastnická práva ke všem Study Data, improvements, developments, discoveries, inventions, work, know-how and other rights (whether or not patentable), created, developed, and/or reduced to practice as a result of or in connection with the conduct of the Study and/or the use of the Study Drug or the Confidential Information, together with all intellectual property rights relating thereto (“Intellectual Property”). The Institution shall promptly disclose in writing to PSI and the Sponsor all Intellectual Property made by the Institution, the Investigator and/or the Study Personnel. At the Sponsor's request, the Institution shall cause all rights titles and interests in and to any such Intellectual Property to be assigned to the Sponsor without additional compensation and provide reasonable assistance to obtain patents, including causing the execution of any invention assignment or other documents. Studijním údajům, vylepšením, na vývoj, k objevům, vynálezům, dílům, know-how a dalším právům (ať už patentovatelným či nikoli), vytvořeným, vyvinutým, a/nebo uvedeným do praxe v důsledku nebo v souvislosti s prováděním Studie, a/nebo používáním Studijního léku nebo Důvěrných informací společně s právy duševního vlastnictví s nimi souvisejícími (dále jen „Duševní vlastnictví“). Poskytovatel bude neprodleně písemně informovat PSI a Zadavatele o veškerém Duševním vlastnictví vytvořeném Poskytovatelem, Hlavním zkoušejícím a/nebo Studijním personálem. Na žádost Zadavatele zajistí Poskytovatel převod veškerých práv a zájmů týkajících se Duševního vlastnictví na Zadavatele bez další odměny a poskytne přiměřenou součinnost k získání patentu včetně zajištění podpisu dokumentů k převodu objevu nebo jiných dokumentů.

  • VOETSTOOTS The PROPERTY is sold:

  • Speech Therapy This plan covers speech therapy services when provided by a qualified licensed provider and part of a formal treatment plan for: • loss of speech or communication function; or • impairment as a result of an acute illness or injury, or an acute exacerbation of a chronic disease. Speech therapy services must relate to: • performing basic functional communication; or • assessing or treating swallowing dysfunction. See Autism Services when speech therapy services are rendered as part of the treatment of autism spectrum disorder. The amount you pay and any benefit limit will be the same whether the services are provided for habilitative or rehabilitative purposes.

  • COVID-19 Residents acknowledge that in March 2020 the World Health Organization declared a global pandemic of the virus leading to COVID-19. The Governments of Canada, the Province of Ontario, and local Governments responded to the pandemic with legislative amendments, controls, orders, by-laws, requests of the public, and requests and requirements to Humber (collectively, the “Directives”). It is uncertain how long the pandemic, and the related Directives, will continue, and it is unknown whether there may be a resurgence of the virus leading to COVID-19 or any mutation thereof (collectively, “COVID- 19”). Without limiting the generality of the foregoing paragraph, Humber shall not be held legally responsible or be deemed to be in breach of this Agreement for any damages or loss arising out of or caused by:

  • WSIB & LTD An Employee who is receiving benefits under the Workplace Safety and Insurance Act, or under a LTD plan, is not entitled to benefits under a school board’s sick leave and short term disability plan for the same condition unless the employee is on a graduated return to work program then WSIB/LTD remains the first payor. For clarity, where an employee is receiving partial benefits under WSIB/LTD, they may be entitled to receive benefits under the sick leave plan, subject to the circumstances of the specific situation. During the interim period from the date of the injury/incident or illness to the date of the approval by the WSIB/LTD of the claim, the employee may access sick leave and short term leave and disability coverage. A reconciliation of sick leave deductions made and payments provided, will be undertaken by the school board once the WSIB/LTD has adjudicated and approved the claim. In the event that the WSIB/LTD does not approve the claim, the school board shall deal with the absence consistent with the terms of the sick leave and short term leave and disability plans.

  • Safety Boots Each employee, after 3 months’ continuous service, will be reimbursed (on production of a receipt), the cost of one pair of safety boots (approved by the employer), in each year, to a maximum of $110.00. Wet Weather All protective clothing such as wet weather jackets, safety helmets, welding jackets, welding xxxxxxx, welding gauntlets, rubber boots, etc, (which remain the property of the Company), will be supplied on all occasions deemed necessary.

Draft better contracts in just 5 minutes Get the weekly Law Insider newsletter packed with expert videos, webinars, ebooks, and more!