Cerebral Cortex Sample Clauses

Cerebral Cortex. In press.

Cerebral Cortex. 11, 2565-77. [3] Xxxxxxx, X. et al. 2010. Neuroimage. 54, 1262-1279 [4] Xxxxx, X. xx. al. 2012.

Cerebral Cortex. 18 1.1.4.4 Thalamus 19

Cerebral Cortex. Cortical expression of group III mGluR mRNA has been detected by in situ hybridization and Northern blot analyses. While group III mGluRs are widely distributed among many cortical regions, there are some cortical areas where mGluR7 mRNA is intensely or moderately expressed without any significant expression of mGluR4 mRNA. These include the neocortical regions, the cingulate, retrosplenial, piriform and perirhinal cortices, superficial layers of the subicular cortex, deep layers of the entorhinal, parasubicular, and presubicular cortices (Xxxxxxx et al., 1996; Corti et al., 2002; Kinzie et al., 1995; Ohishi et al., 1995; Okamoto et al., 1994). In the cerebral cortex, both the mGluR4 mRNA and protein has been detected using in situ, immunoblotting and mGluR4 immunoreactivity was observed in a clear laminar pattern in all deep cortical areas (layer IV/V interface) from the frontal to entorhinal cortex inclusive (Xxxxxxx et al., 1996; Xxxxxxx et al., 1994; Xxxxxxxx et al., 1997). The morphology and density of immunopositive cortical cells suggests that they are not all pyramidal output cells, but may represent a subpopulation cortical interneurons or stellate cells (Ohishi et al., 1995; Xxxxxxxx et al., 1997). Shortly after, immunohistochemical analysis by Xxxxxx et al. (2001) identified mGluR4a-positive corticostriatal projection neurons in deep cortical layers. In situ hybridization with the mGluR7 cRNA probe produced a pattern of hybridization signal identical to the distribution found in previous studies (Kinzie et al., 1995; Ohishi et al., 1995). In cerebral cortex, the labeling was most intense in the occipital cortex and slightly less intense in frontal cortical areas. Immunohistohemical analysis of cortical tissue confirmed the localization of mGluR7 in the rodent cortex (Xxxxxxxx et al., 1999). Thus it is possible that group III mGluRs are expressed in cortical interneurons and projection neurons.