Dermal studies. Following the ex- perimental guidance described in (c)(2)(iii)(A)(3) of this section:
Dermal studies. The test substance shall be applied and kept on the skin for a minimum of 6 hours. The covering apparatus components shall be assayed to recover residual radioactivity. At the termination of the studies, each animal shall be sacrificed and the ex- posed skin area removed. An appro- priate section of the skin shall be solu- bilized and assayed for radioactivity to ascertain whether the skin acts as a reservoir for the test substance.
Dermal studies. Unless precluded by corrosivity, the test substance shall be applied and kept on the skin for a minimum of 6 hours. At the time of re- moval of the porous covering, the treated area shall be washed with an appropriate solvent to remove any test substance that may be on the skin sur- face. Both the covering and the wash- ing shall be assayed to recover residual radioactivity. At the termination of the studies, each animal shall be sac- rificed and the exposed skin area re- moved. An appropriate section of the skin shall be solubilized and assayed for radio-activity to ascertain if the skin acts as a reservoir for the test substance. Studies on the dermal ab- sorption of corrosive test substances should be discussed with EPA prior to initiation.
