Description of work and efforts. The CCDC uses a multi-tiered architecture compatible with other BBMRI CS-IT systems (Xxxxxxxxx et al. 2016). Figure 1 is a schematic representation of the finalized architecture. Figure 1 Architecture of the CCDC The central element is the database which stores the colon cancer data. The data model is described in the metadata repository, to allow for harmonization with other data sources. As the original data is unlikely to be structured according to our data model in the source biobanks’ systems, ETL adapter scripts are needed for semi-automated data transfer. For biobanks whose systems do not have the needed interfaces for a semiautomatic ETL, their data is manually entered into the database via a specialized interface. When the CCDC is deployed, users will be able to access and search the data via a search interface. Privacy and security issues are addressed through the use of a dedicated authentication and authorization service, which allows role based access control. The current deliverable encompasses following artefacts: • Data dictionary, a set of defined common data elements to be used for data entry via the manual data entry interface (Linarsson and Wigertz 1989) • Metadata repository, a collection of metadata records corresponding to the data elements of the data dictionary (Strausberg et al. 2009) • Electronic case record forms (eCRF), a software component which allows a data specialist to enter colon cancer data • Data storage, a database instance which can save the data entered in the data entry interface • Role concept, a description of the roles and their permissions needed for creating and maintaining the collection The ETL adapters, the search interface and the authentication and authorization software component will be delivered in a later stage, as agreed in the ADOPT project proposal.
