Common use of Design Strategy Clause in Contracts

Design Strategy. The DF and PS1 scaffolds differ in the inter- helical separation and registry of their four-helix bundle domains (SI Appendix, Fig. S1). Therefore, it was necessary to design linkers that connect the two bundles in an energetically reasonable manner. To accomplish this, the helical bundles were connected using a structure-based design strategy involving two interrelated steps: first, the optimal relative translation and orientation be- tween the bundles, namely the bundle placement, were deter- mined; second, a structural solution interconnecting each of the disjointed helices between the domains was identified. In the most general case, the bundle placement involves searching a six-dimensional space, comprising three translational