Emulsification–solvent diffusion Sample Clauses

Emulsification–solvent diffusion. The emulsification solvent diffusion or emulsification-solvent displacement method is the most widely used method for preparing nanoparticles due to several advantages. These include high drug entrapment efficiency for poorly water soluble drugs, narrow particle size distribution, high batch-to-batch reproducibility, no requirement for homogenization, simplicity, ease of scale up and rapid organic solvent extraction (Xxxxxxx-Xxxxxx et al., 2006). The drug and polymer are dissolved in a partially water soluble solvent. The organic phase is saturated with water to ensure the initial thermodynamic equilibrium. It is then diluted with an extensive amount of pure water to facilitate diffusion of the organic solvent from the organic phase droplets leading to the precipitation of the polymer. The aqueous phase may contain surfactants while the organic phase sometimes contains an emulsifier. Finally, the solvent is eliminated by evaporation or filtration, depending upon the boiling point. Several parameters can affect the size of the nanoparticles such as miscibility of the water with the organic solvent, stirring rate, concentration of the surfactant(s) and concentration of the polymer is the organic phase.
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