Methods for the Synthesis Sample Clauses

Methods for the Synthesis of 1,2,4-Trisubstituted Piperidines‌ Since substituted piperidines ring systems are found in a diverse range of bioactive natural products, the pharmaceutical industry has developed great interest in obtaining such compounds in a stereoselective manner. Currently, the N (1),C (4)-disubstitution pattern prevails amongst drugs in the clinic and therefore the easy access to steroselec- tively substituted piperidines, such as N (1),C (2),C (4)-trisubstituted building blocks, is highly desirable in order to gain further structure-activity related information on existing and new pharmaceuticals. Many different approaches towards the synthesis of a multi-substituted piperidine core exist, and review literature illustrates the current interest in this important area of organic chemistry. 35–40 Out of this large amount of different strategies available for the synthesis of substituted piperidines, examples specifically for the stereoselective synthesis of 1,2,4-trisubstituted piperidines will be presented in the following section, emphasising the key steps of these routes.