Mitochondria and ROS in PD Sample Clauses

Mitochondria and ROS in PD the chicken or the egg? The mitochondria-associated deficiencies discussed above all result in the increased production of ROS. However, they can also arise as a result of ROS activity. Therefore, it is difficult to conclusively determine which factor, whether mitochondrial dysfunction or a highly-oxidative environment, initiates this vicious cycle. However, as discussed in the following section, dopaminergic neurons possess a distinct intracellular environment that may hold the clues to what is occurring during the early stages of PD development.
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