Motor activity. (A) Motor activity shall be monitored specifically on days 13, 17, 21, 45 (±2 days), and 60 (±2 days). Motor activity shall be monitored by an automated activity recording appa- ratus. The device used shall be capable of detecting both increases and de- creases in activity, i.e., baseline activ- ity as measured by the device shall not be so low as to preclude decreases nor so high as to preclude increases. Each device shall be tested by standard pro- cedures to ensure, to the extent pos- sible, reliability of operation across de- vices and testing of animals within dose groups shall be balanced across devices.
