Observation of dams. (i) A gross ex- amination of the dams shall be made at least once each day, before daily treat- ment. The animals shall be observed by trained technicians who are blind with respect to the animal’s treatment, using standardized procedures to maxi- xxxx inter-observer reliability. Where possible, it is advisable that the same observer be used to evaluate the ani- mals in a given study. If this is not possible, some demonstration of inter- observer reliability is required.
Observation of dams. ( i) A g r oss ex- a m i n a t io n of t h e d a m s s h a ll be m a de a t le a s t o n ce e a c h d a y , befo r e d a il y t r e a t - m e n t . T h e a n i m a l s s h a ll be obse r ved b y t r a i n ed t ec hn ici a n s w h o a r e bli n d wi t h r espec t t o t h e a n i m a l’s t r e a t m e n t , u s i n g s t a n d a r dized p r oced ur es t o m a xi- m ize i n t e r - obse r ve r r eli a bili t y . Wh e r e possible, i t i s a dvis a ble t h a t t h e s a m e obse r ve r be u sed t o ev a l u a t e t h e a n i- m a l s i n a give n s t u d y . If t h i s i s n o t possible, so m e de m o n s t r a t io n of i n t e r - obse r ve r r eli a bili t y i s r eq u i r ed.
