Common use of Schedule of Changes Clause in Contracts

Schedule of Changes. Sponsor and Omnicare CR agree to the following changes and additional work pursuant to the general terms and Conditions set forth in the Agreement: Estimated Service Reference Changes and/or Additions Fee (AUS$) Pursuant to Exhibit E, Omnicare CR will provide biometrics support for the Sponsor’s statistical consultation requirements in Australia, New Zealand and the US Additional Statistical Consultation: • Australian Statistician **** hours @ A$**** per hour • US Statistician **** hours @ A$**** per hour (US$****/hour exchanged at 1.2934 = AUS$****/hour) **** **** Total Estimated Service Fees **** * Total Estimated Pass Through Expenses **** ** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.

Schedule of Changes. Sponsor and Omnicare Omicare CR agree to the following changes and additional work pursuant to the general terms and Conditions conditions set forth in the Agreement: Estimated Service Reference Changes and/or Additions Estimated Service Fee (AUS$) Pursuant to Exhibit EA, Omnicare CR will provide biometrics additional clinical data management support for the Sponsor’s statistical consultation requirements Cohort Study of PEP005 Topical Gel, Protocol # PEP005-004, Version 3 Edit Development: * Estimated number of edit checks in Australia, New Zealand and the US Additional Statistical Consultation: • Australian Statistician original budget = ****. * Actual number of edit checks = ****. * Variance = **** hours edit checks @ A$**** per hour • US Statistician **** hours @ A$**** per hour (US$****/hour exchanged at 1.2934 = AUS$****/hour) AUS$**** **** Total Estimated Service Fees **** * Total Estimated Pass Pass-Through Expenses Expense **** ** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.,

Schedule of Changes. Sponsor and Omnicare Omicare CR agree to the following changes and additional work pursuant to the general terms and Conditions conditions set forth in the Agreement: Estimated Service Reference Changes and/or Additions Fee (AUS$) Pursuant to Exhibit EA, Omnicare CR will provide biometrics additional clinical data management support for the Sponsor’s statistical consultation requirements Cohort Study of PEP005 Topical Gel, Protocol # PEP005-004, Version 3 Edit Development: * Estimated number of edit checks in Australia, New Zealand and the US Additional Statistical Consultation: • Australian Statistician original budget = ****. * Actual number of edit checks = ****. * Variance = **** hours edit checks @ A$**** per hour • US Statistician **** hours @ A$**** per hour (US$****/hour exchanged at 1.2934 = AUS$****/hour) AUS$**** **** Total Estimated Service Fees **** * Total Estimated Pass Pass-Through Expenses Expense **** ** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.,

Schedule of Changes. Sponsor and Omnicare Omicare CR agree to the following changes and additional work pursuant to the general terms and Conditions conditions set forth in the Agreement: Estimated Service Reference Changes and/or Additions Estimated Service Fee (AUS$) Pursuant to Exhibit EA, Omnicare CR will provide biometrics additional clinical data management support for the Sponsor’s statistical consultation requirements Cohort Study of PEP005 Topical Gel, Protocol # PEP005-004, Version 3 Edit Development: * Estimated number of edit checks in Australia, New Zealand and the US Additional Statistical Consultation: • Australian Statistician original budget = ****. * Actual number of edit checks = ****. * Variance = **** hours edit checks @ A$**** per hour • US Statistician **** hours @ A$**** per hour (US$****/hour exchanged at 1.2934 = AUS$****/hour) AUS$**** **** Total Estimated Service Fees **** * Total Estimated Pass Pass-Through Expenses Expense **** ** Total Estimated Budget **** **** Certain confidential information contained in this document, marked with four asterisks, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 24b-2 of the Securities Exchange Act of 19331934, as amended. * The Estimated Service Fees set forth above represent the original unit costs set forth in the Agreement and are subject to any annual price increase(s) applied against the original unit costs. ** Sponsor will be billed for actual Pass-Through Expenses incurred in support of the Project.,