Serotonin: 5-HT3 Sample Clauses

Serotonin: 5-HT3. The ionotropic 5-HT3 receptor has also been implicated in PSI of primary afferents. In particular, Xxxxxxxx et al showed that 5-HT3 agonists depressed EPSPs in dorsal horn neurons of the young rat following stimulation of primary afferents at intensities sufficient to recruit all afferent fiber types (Xxxxxxxx, Xxxxx-Xxxxxx et al. 1999). Furthermore, in situ hybridization showed a loss of 5-HT3 binding, particularly in the superficial dorsal horn following unilateral rhizotomy (Kia, Miquel et al. 1995). A similar loss of 5-HT3binding was seen after capsaicin-induced ablation of small unmyelinated afferents (Xxxxx, Gallissot et al. 1989). Combined, these studies suggest 5- HT3 receptor involvement in PSI of small unmyelinated nociceptive afferents.
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