Statistical Methods in Preprocessing Proteomics Data Sample Clauses

Statistical Methods in Preprocessing Proteomics Data. The typical first step in proteomics data analysis is the removal or reduction of sys- tematic artifacts introduced by the instrumentation and experimental protocols, and by the random background fluctuations produced by chemical and electronic noise. Secondly, spectra from multiple MS runs need to be aligned with respect to reten- tion time of the compounds. These prerequisite data adjustment steps are known as preprocessing, and at a minimum, involve the following steps: spectrum calibration; base-line correction; smoothing; peak identification; and intensity normalization and
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