Lead Antibody definition

Lead Antibody means (i) any RON Antibody that has been identified by AVEO prior to the Effective Date; (ii) any RON Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term; (iii) any RON Antibody that is a derivative of any of the Antibodies described in clauses (i) or (ii) identified or generated anytime after the first [**] months of the Research Term but excluding any such derivative Antibody under this clause (iii) that [**] described in clause (i) or (ii) above; and (iv) in each case under clauses (i),(ii) and (iii), any binding fragment of such RON Antibody and any such RON Antibody or binding fragment conjugated or fused to any other polypeptide.

Lead Antibody means a Program Antibody that meets the Lead Selection Criteria as determined by the Joint Research Committee.

Lead Antibody means the [*****]

Examples of Lead Antibody in a sentence

• If the Joint Research Committee determines that the Lead Data Package is complete and that such Program Antibody meets the Lead Selection Criteria as set forth in the Antibody Progression Manual, it shall approve the Lead Data Package and such Program Antibody shall thereafter be designated as a Lead Antibody, subject to Section 3.4 of this Agreement.

• Neither Party shall publish the sequence of the Licensed Lead Antibody Compound or information concerning the manufacture of the Licensed Lead Antibody Compound without the prior written consent of the other Party.

• The Parties shall use their respective commercially reasonable efforts to deliver and receive the Licensed Materials, as appropriate, through electronic delivery (other than Licensed Lead Antibody Compound drug substance and any other tangible inventory included in the Licensed Material) or in such other manner reasonably calculated in accordance with applicable law, and take all other commercially reasonable actions necessary, to minimize or avoid the incurrence of any such taxes or fees.

• On a Lead Antibody, EDC Antibody, Licensed Antibody and Licensed TAP Antibody basis, Aventis hereby grants to ImmunoGen and its Affiliates a non-exclusive, non-sublicensable, royalty-free license, under the Aventis Intellectual Property and the Program Intellectual Property, to Develop Products in the manner and to the extent such Development is assigned to ImmunoGen by the Joint Development Committee.

• The transfer of Licensed Lead Antibody Compound drug substance inventory and consumables within the Licensed Materials constitutes a transfer of all right, title and interest in and to such materials, provided that XXXXX may use such materials solely to Exploit Licensed Products in accordance with this Agreement.

More Definitions of Lead Antibody

Lead Antibody means (i) any XXX Antibody that has been identified by AVEO prior to the Effective Date; (ii) any XXX Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term; (iii) any XXX Antibody that is a derivative of any of the Antibodies described in clauses (i) or (ii) identified or generated anytime after the first [**] months of the Research Term but excluding any such derivative Antibody under this clause (iii) that [**] described in clause (i) or (ii) above; and (iv) in each case under clauses (i), (ii) and (iii), any binding fragment of such XXX Antibody and any such XXX Antibody or binding fragment conjugated or fused to any other polypeptide.

Lead Antibody has the meaning specified in Section 7.3.4(a) hereof.

Lead Antibody means (i) any XXX Antibody that has been identified by AVEO prior to the Effective Date; (ii) any XXX Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term;

Lead Antibody means MDX-010, which has the amino acid sequences for CDR 1, 2 and 3 of the heavy chain variable region as Previously Disclosed.

Lead Antibody means the VAP-1 Antibody selected by BioTie (BTT-1023, known to Medarex as MDX-1352) to become the subject of an Exclusive Commercial License and whose Binding Sequence is set forth in Exhibit B. A Backup Antibody may be substituted for a Lead Antibody pursuant to Section 2.1.2.

Lead Antibody means the humanized anti-human PD-1 monoclonal antibody SHR- 1210, as exemplified by the sequence in Exhibit A.

Lead Antibody means the humanized anti-human PD-1 monoclonal antibody SHR-1210, as exemplified by the sequence in Exhibit A. [**] = Portions of this exhibit have been omitted pursuant to a confidential treatment request. An unredacted version of this exhibit has been filed separately with the Commission.