Mechanism of Action definition

Mechanism of Action means, with respect to a target, modulation of such target by a compound via a given mechanism of action (whether inhibition or activation).
Mechanism of Action or “MOA” means each of the DCM1 MOA, the HCM1 MOA and the HCM2 MOA.
Mechanism of Action means Orexin-1 receptor antagonism,

Examples of Mechanism of Action in a sentence

  • Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.

  • Structure and Mechanism of Action of Sda, an Inhibitor of the Histidine Kinases that Regulate Initiation of Sporulation in Bacillus subtilis.

  • Language learners and users should be made aware of these issues and invited to take great care in choosing and using non-verbal strategies.

  • Mechanism of Action & Proof-of-Concept▪ 4 patients treated by Dr. Wiseman in 2004-2005 (original patients), including one remarkable responder.▪ 23 patients were dosed in 2017-2018 (Phase I/IIa), all very heavily pre-treated (with chemotherapy).▪ Safety & Efficacy Data: We believe the data was similar or superior to those of other advanced or approved drugs for breast cancer at similar stages of clinical development.

  • Mechanism of Action: The active ingredient in this product inhibits an enzyme found only in plants and microorganisms that is essential to the formation of specific amino acids.No Soil Activity: This product binds tightly to soil particles and does not provide residual weed control.


More Definitions of Mechanism of Action

Mechanism of Action means the binding to the nuclear export protein, Exportin 1, or XPO1, causing inhibition of the activity of XPO1 or otherwise reducing the nuclear export of XPO1’s cargo proteins.
Mechanism of Action. The epipodophyllotoxins exert phase specific spindle poison activity with metaphase arrest, but in contrast to the vinca-alkaloids, have an additional activity of inhibiting cells from entering mitosis. Suppression of tritiated thymidine, uridine, and leucine incorporation in human cells in tissue culture suggests effects against DNA, RNA, and protein synthesis.
Mechanism of Action shall have the meaning ascribed to it in Section 6.1.1 hereof.
Mechanism of Action means [***] "Net Sales" means, with respect to a Licensed Product, for any reference period, the gross amount invoiced by[***] :
Mechanism of Action or “MoA” means the results on the [********] criteria set forth on Schedule 1.82 (based on the corresponding measurement set forth on Schedule 1.82) at the applicable Protein Target Profile, taking each such criterion into account. A compound has “substantially the same” Mechanism of Action or MoA as another compound if (i) the two compounds have the same Protein Target Profile and the results of the first compound and the second compound on each of such measurements at [********] the NNR Subtypes included in the applicable Protein Target Profile are [********] for such measurement shown on Schedule 1.82 (provided that, where there are alternative measurements (or assays used to make such measurement) that may be applicable for a particular criterion (i.e., [********]) determination of whether any compound has substantially the same Mechanism of Action as another compound shall be made using the same measurement(s) (or assay(s)) as was used by Targacept to make such measurement with respect to such first compound) and (ii) neither compound has activity in any material respect [********] at which the other compound does not have activity in any material respect.
Mechanism of Action means that the relevant Third Party FOB binds to the same antigen as the Product.
Mechanism of Action means the specific biological and/or chemical interaction(s) through which a drug substance produces its pharmacological effect(s).