Biotrasformation. Indirect information regarding the metabolism of lanreotide is obtained from studies in special populations, which suggest that the kidney plays a more relevant role in the metabolism of lanreotide than the liver. No other clinical data regarding the metabolism of lanreotide are available (8). The urinary and faecal excretion of lanreotide is minimal and represents only a small fraction of lanreotide elimination while the recovery of unchanged lanreotide in faeces is indicative of biliary excretion. In studies evaluating excretion, <5% of lanreotide was excreted in urine and less than 0.5% was recovered unchanged in feces, indicative of some biliary excretion (8).
