Antivirals Sample Clauses

Antivirals. 13.1. The medical service is responsible for the purchase and storing the Agencies’ stock. However, this stock is the property of the Agencies. The Agencies shall bear the costs of the purchase and storage. 13.2. The medical service is responsible for suitable security of this stock and to ensure enhanced security in the event of a pandemic threat. 13.3. The medical service shall make it available within two days of the notification by the Agencies together with suitably qualified staff for prescription purposes. The Agencies will bear the costs for the appointments for any staff member to prescribe the medicine and should be invoiced directly.
Sample 1
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Antivirals. Avoid combination therapy containing simeprevir and sofosbuvir due to risk of severe bradycardia and heart block; Unless other antiarrhythmics cannot be given • Grapefruit juice inhibits cytochrome P450 3A4 and may increase the plasma concentration of amiodarone. Grapefruit juice should be avoided during treatment with oral amiodarone • Laxatives (stimulant): Stimulant laxatives e.g. Bisacodyl, Senna may cause hypokalaemia and increase the risk of torsades de pointes. Concomitant use with amiodarone are cautioned: • Anticoagulants: Warfarin clearance is reduced. This can lead to sudden and pronounced increase in INR. Interaction reaches its peak in 6-7 weeks. Reduce warfarin dose and monitor weekly, tailoring the warfarin dose to the INR target. • Amiodarone increases the exposure to dabigatran thus increase the risk of bleeding. Adjust the dosage of dabigatran according to manufacturers’ advice (note dose may be different for different clinical indications). • Cardiac Glycosides: Plasma level of Digoxin approximately doubles over weeks after commencement of amiodarone. Reduce dose and monitor digoxin level if applicable • Beta-blockers: Potentiation of negative chronotropic properties and conduction slowing effects may occur. • Calcium channel inhibitors: Rate lowering calcium channel inhibitors e.g. Diltiazem, verapamil potentiates negative chronotropic properties and conduction slowing effects may occur (under specialist advice only) • Ciclosporin: Plasma level of ciclosporin increased when used with amiodarone. Manufacturer advises monitor concentration and adjust dose. • Drugs that may cause hypokalaemia/ hypomagnesaemia / hypokalaemia/ hypomagnesaemia: Caution should be exercised over combined therapy with the following drugs which may also cause hypokalaemia: and/or hypomagnesaemia e.g. diuretics, systemic corticosteroids, tetracosactrin, IV amphotericin, aminophylline, theophylline • Statins: the risk of muscular toxicity (e.g. Rhabdomyolysis) is increased by concomitant administration of amiodarone with statins metabolised by CYP 3A4 such as simvastatin, atorvastatin, and lovastatin. It is recommended to use a statin not metabolised by CYP 3A4 when given with amiodarone. • Phenytoin: Plasma level of phenytoin increased with amiodarone. Phenytoin dosage should be reduced in signs of overdosage and plasma levels may be measured • Ticagrelor: Manufacturer advises use with caution or avoid. Cost: At current prices one year’s treatment of £31.72 at a d...
Sample 1

Related to Antivirals

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