Chemical responsive Sample Clauses

Chemical responsive. Triggered delivery systems that do not use specialist equipment for administration and where the process can be easily controlled, e.g. systems requiring co-administration of chemical triggers, offer a more convenient approach. Surfactant-induced leakage from liposomes has been studied. For example, Pluronic F127 (PF127) is a biocompatible tri-block copolymer, which can interact with lipid bilayer of liposomes and make leakage that allow the release of hydrophilic substance from liposome interior (Xxx et al., 2014). Similarly, lipid nanoparticles engineered with a solid outer shell, could be selectively and rapidly permeabilised using the amphiphilic polymer Pluronic® L62D as a chemical trigger (Xxxxx et al., 2015). Apart from surfactant, sugar can be used to trigger copolymers through hydrolysis (Xxx et al., 2008). Similarly glucose-induced swelling attributed to the slow reaction between glucose and phenylboronic acid (PBA) groups enabled microgel suitable for sustained drug delivery (Xxxx et al., 2011). Some polymer films such as poly (2-vinylpyridine) is also responsive to cholesterol molecules, thus the material can be used to manufacture stimuli responsive nanomaterials for controlled release (Xxxxxx et al., 2010). However only surfactant have been tested for pulmonary drug delivery.
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