Child maltreatment and inflammation Sample Clauses

Child maltreatment and inflammation. The link between child maltreatment and inflammation was first demonstrated in the Dunedin Multidisciplinary Health and Development Study (DMHDS). The DMHDS is a prospective longitudinal birth cohort study based in New Zealand that has followed over 1,000 individuals from early childhood to age 32. Xxxxxx and colleagues, including my second supervisor Xxxx Xxxxxxxx (2007), showed that maltreatment in childhood predicted high inflammation, as indexed by plasma CRP levels at 32 years. This effect was independent of stress in adulthood, health and lifestyle factors and co-occurring early life risks. Furthermore, CRP levels were observed to be highest amongst individuals who experienced current depression and had a history of child maltreatment (Xxxxxx et al., 2008). More recently, in a retrospective study involving 1,000 US adults, cumulative early life stress, which included childhood experiences of abuse and neglect, was found to be positively associated with elevated CRP, IL-6 and adhesion molecules (Slopen et al., 2010). In a study (n =
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