Description of Directed Array™ Programs Sample Clauses

Description of Directed Array™ Programs. Subject to the approval of the Research Committee and the provisions of Section 4.2, ArQule will synthesize, under the direction of the Research Committee and in accordance with the Research Plan, multiple Directed Arrays™ of compounds derived from (i) each Wyeth-Ayerst Compound provided to ArQule by Wyeth-Ayerst for inclusion in a Directed Array™ Program, and/or (ii) each Active ArQule Compound or Active Homolog thereto provided by ArQule to Wyeth-Ayerst under the Mapping Array™ Program for inclusion in a Directed Array™ Program. The Parties agree that, during the period provided for in Section 4.5, ArQule will produce such Directed Arrays™ in no less than * separate Directed Array™ Programs as follows: (i) Directed Array™ Programs during the Initial Contract Year of 1997, (ii) Directed Array™ Programs during each of the Contract Years of 1998 and 1999, and (iii) Directed Array™ Programs commenced during the Final Contract Year. The Research Committee will determine which Active ArQule Compounds or Active Homologs thereto, and which Wyeth-Ayerst Compounds are actually submitted to the Directed Array™ Programs. Subject to Research Committee approval and oversight, it is expected that each Directed Array™ Program should take * to complete, with an average of * for the Directed Array™ Programs commenced in any Contract Year. In the event that such average exceeds * in any Contract Year, the matter will be referred to the Research Committee to develop a plan to accelerate the Directed Array™ Programs. Failure to average * or less to complete the Directed Array™ Programs for any Contract Year shall not be a material breach sufficient to terminate this Agreement pursuant to Section 12.3. Each Directed Array™ program shall result in the production of approximately * to about * compounds per Chemical Theme per Directed Array™ Program resulting in approximately * to * compounds generated for the * Directed Array™ Programs, provided, however, that the number of Chemical Themes actually submitted to the Directed Array™ Program and the number of ArQule Derivative Compounds or Wyeth-Ayerst Derivative Compounds actually produced per Chemical Theme will be determined by the Research Committee. ArQule shall devote the resources necessary to produce such Directed Array™ Program commensurate with the payments received by ArQule for such Directed Array™ Program and ArQule agrees that the determination of the actual numbers of compounds developed per Directed Array™ Program ...
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