Epithelial Ovarian Cancer Sample Clauses

Epithelial Ovarian Cancer. Ovarian cancer is a lethal disease with 22,530 new cases and 13,930 deaths expected in 2019 in the US (SEER Cancer Statistics Factsheet 2019). The estimated number of new EOC cases in the EU (EU27) in 2012 was 44,149 with 29,758 deaths (EUCAN Cancer Fact Sheet: Ovary 2019). The overall 5-year survival for EOC patients is only 48% (SEER Cancer Statistics Factsheet 2019). Recent studies indicate that ovarian, peritoneal, and fallopian tube cancers are not distinct entities, but represent a spectrum of diagnoses that originate in the Mullerian tissue. Primary fallopian tube carcinoma and peritoneal cancers are now included in the ovarian cancer staging classification (Xxxx 2015, Xxxxx 2010, Xxxxxxx 2011, O’Shannessy 2013), and are considered to be part of EOC with the same treatment and outcomes. Despite considerable improvements in primary therapy, 80% of the patients with advanced EOC are expected to relapse during or after treatment with platinum-containing regimens (Xxxxxxxxx 2019). Disease recurring within 6 months of platinum-based chemotherapy is classified as platinum resistant, whereas, disease recurring longer than 6 months after therapy is termed platinum sensitive. Patients with platinum-resistant disease typically receive single-agent chemotherapy (eg, PLD, topotecan [Topo], gemcitabine, paclitaxel [Pac], or other) at relapse. Unfortunately, response rates (RR) are modest (~15%) and duration of response (DOR) is typically 4 to 8 months (Xxxxxxxxx 2010, Matsuo 2010). Similarly, overall survival (OS) is poor (median OS ~11 months). Bevacizumab was approved for use in combination with chemotherapy for recurrent EOC in the platinum-resistant setting (Pujade-Xxxxxxxx 2014). Because platinum-resistant EOC (PROC) remains a significant unmet medical need, the National Comprehensive Cancer Network (NCCN) guidelines recommend that platinum resistant patients participate in clinical trials (NCCN Guidelines 2019). Commonly used agents for PROC are Pac, Topo and PLD, all of which have modest levels of activity, which underscores the need for improved therapies. In addition to single-agent cytotoxic chemotherapy, bevacizumab combinations and poly-ADP ribose polymerase (PARP) inhibitors (eg, olaparib, niraparib, and rucaparib) are approved for treatment of previously treated EOC. These agents, however, are subject to treatment limitations. In particular, bevacizumab combinations are limited to patients who have received no more than 2 prior chemotherapy regimen...
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