Filarial cause of ADL Sample Clauses

Filarial cause of ADL. The other primary view on the cause of ADL episodes attributes them to the host’s inflammatory/immune response to adult worm activity in the lymph system or microfilariae in the blood. A study of 63 established cases of acute filarial fever in Puri District, Odisha State, India found a significant rise in the microfilaria count during the acute episode compared to 1 month before and 1 month after the episode [62] suggesting fresh circulation of mf during the fever. It also found a significant decrease in the mean OD levels of filarial-specific IgG and IgG4 during the episode, a significant increase in the mean level of circulating immune complex (CIC = antibody + antigen) during the attack, suggesting that the excess antigen released into circulation during the episode had formed immune complexes after bonding to antibodies. Lastly, the study demonstrated no significant difference between the percentages of patients with a positive anti- streptolysin O (ASO) test (an indicator of recent streptococcal infection) before, during, or after the episode. In conclusion, this study suggests that the immune-mediated response to adult filarial worms may have induced the ADL episodes among these patients. This may have been triggered by a new parturition of microfilariae released by the mother prior to the episode.
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