Glomerular histology Sample Clauses

Glomerular histology. The morphology of the focal segmental glomerulosclerosis (FSGS) lesions was highly variable, ranging from segmental collapse of a few capillaries to advanced global sclerosis. (A) An early lesion with segmental capillary collapse and epithelial hyper- plasia (arrows). Some of the epithelial cells have prominent resorpsion droplets. The upper part of the glomerulus appears unremarkable. (B and C) Glomeruli show more extensive abnormalities with on top of col- lapsed capillaries with epithelial hyperplasia more advanced (“typical”) FSGS lesions (arrowheads) with sclerosis, adhesions, epithelial hyper- plasia, and mild endocapillary hypercellularity with endocapillary foam cells. (D) A hypocellular globally sclerotic glomerulus covered with a single layer of epithelial cells, which do not appear, activated (×450). Amsterdam The Netherlands). Two micrometer sections were stained with periodic acid-Schiff (PAS), and with silver methenamine [15]. Immunohistochemistry. Immunohistochemical stain- ing was performed on kidney sections fixed in 4% buffered formaldehyde for 24 hours and embedded in paraffin. Four micrometer sections were incubated with monoclonal antibodies and polyclonal antibod- ies directed at various markers for podocytes, PECs, macrophages, and myofibroblasts as detailed in Table
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