Invasive diagnostic work-up Sample Clauses

Invasive diagnostic work-up. Within two months from enrolment and after the completion of the non invasive work-up, patients will undergo invasive study. Coronary angiography (ICA) will be proposed to all patients since it is currently accepted in patients with intermediate pre-test probability of IHD even without further non invasive testing. Patients who will refuse ICA, in particular in the case of negative non- invasive testing, will be kept into the study. Intracoronary estimate of fractional flow reserve (FFR) by pressure wire will be performed as golden standard to assess the “functional” significance of an intermediate coronary lesion >=30% (obligatory in stenoses 30%-70%) and as a guide to indicate revascularization (also in stenoses >70% if judged clinically useful by the cath operator). Intracoronary ultrasound (IVUS) will be performed in patients with angiographycally normal coronary vessels or <30% coronary stenoses for accurate evaluation of early epicardial coronary atherosclerosis. For lower than 30% stenosis, coronary flow reserve (by Doppler wire) will be also measured to assess coronary microvascular function. All studies will be performed according to standardized protocols, registered on multimedial support (DVD) in standardized formats and shipped for central analysis. Records of measured radiation dose to the patient will be entered in the “patient record” into the Central Server.
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