LEAD cohort Sample Clauses

LEAD cohort. The Xxxxxx-Xxxxx survival probabilities in 1 year, 3 years and 5 years in terms of three outcomes were summarized in Table 2 and the survival curves comparing two relapse detection groups were shown in Figure 1. Hazard ratios (HRs) and p-values given by all the Xxx PH models in LEAD cohort were summarized in supplementary Table S1. The estimated median PFS time in this cohort is 4.2 years (95% CI: 2.5-6) in clinical detection group and 3.6 years (95% CI: 1.8-4.4) in SI detection group. Although it seemed that SI led to an earlier detection of relapse based on median PFS time, there was no statistically significant difference in survival probabilities between two groups with a p-value of 0.2895 given by the two-sample log-rank test. The simple Xxx PH model gave the same result with a p-value of 0.291 in Wald test (HR of SI group=1.37, 95% CI: 0.76-2.45). After controlling for the confounders – ethnicity, ECOG, FLIPI, B- symptoms and age, no apparent difference in patient survival was detected from the multivariable model (HR of SI group=1.71, 95% CI: 0.77-3.80, p-value=0.187). In terms of the other two survival outcomes, survival probabilities and risk of death were also not significantly different between patients in two groups. For OS from diagnosis, the p-value was 0.5324 in log-rank test and 0.537 in simple Xxx model (HR of SI group=0.61, 95% CI: 0.13-2.94). In the multivariable Xxx model with covariates gender, stage, grade, ECOG, B-symptoms and age, the HR was 0.14 (95% CI: 0.01-3.36) with a p-value of 0.222. For OS from relapse, the p-value was 0.3346 in log- rank test and 0.346 in simple Xxx model (HR of SI group=0.47, 95% CI: 0.10-2.28). In the multivariable Xxx model with covariates grade and ECOG, the HR was 0.28 (95% CI: 0.03-2.51) with a p-value of 0.255. Results of the Supremum tests for checking proportional hazard assumption in the three multivariate Xxx models in LEAD cohort were summarized in Table S3. None of the variables included in the three models violated the PH assumption as all the test results were non- significant at the alpha level of 0.05.
Sample 1
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