Management of Atezolizumab-Specific Adverse Events Sample Clauses

Management of Atezolizumab-Specific Adverse Events. Additional tests, such as autoimmune serology or biopsies, should be used to determine a possible immunogenic etiology. Although most immune-mediated adverse events observed with immunomodulatory agents have been mild and self-limiting, such events should be recognized early and treated promptly to avoid potential major complications. Discontinuation of atezolizumab may not have an immediate therapeutic effect and, in severe cases, immune-mediated toxicities may require acute management with topical corticosteroids, systemic corticosteroids or other immunosuppressive agents. Abdominal pain Acute Abdominal pain Symptoms of abdominal pain associated with elevations of amylase and lipase, suggestive of pancreatitis, have been associated with administration of other immunomodulatory agents. The differential diagnosis of acute abdominal pain should include pancreatitis. Appropriate workup should include an evaluation for obstruction, as well as serum amylase and lipase tests. See the guidelines for “Amylase and/or lipase increase” and “Immune- related pancreatitis” elsewhere in this table, as needed. Right upper-quadrant abdominal pain and/or unexplained nausea or vomiting should be evaluated for potential hepatotoxicity (see the “Hepatotoxicity” guideline elsewhere in this table). Adrenal insufficiency Grade 2+ Hold atezolizumab. (symptomatic) Consider referral of patient to endocrinologist. Perform appropriate imaging. Initiate treatment with 1−2 mg/kg/day intravenous methylprednisolone or equivalent and convert to 1−2 mg/kg/day oral prednisone or equivalent upon improvement.
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Related to Management of Atezolizumab-Specific Adverse Events

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