Management of Blood Pressure Sample Clauses

Management of Blood Pressure. Investigators should attempt to maintain the blood pressure within the range recommended by the Kidney Disease Blood Pressure Working Group (KDIGO): ≤ 140 mm Hg systolic and ≤ 90 mm Hg diastolic for patients with UACR < 30 mg/g, and ≤ 130 mm Hg systolic and ≤ 80 mmHg diastolic for patients with UACR > 30 mg/g (KDIGO, 2012). Patients should receive the maximally tolerated labeled daily dose (MTLDD) of an ACE inhibitor and/or ARB, which is defined as the dose at or below the labeled dose that does not exhibit any intolerable adverse effects (e.g., hypotension, hyperkalemia), based on the investigator's assessment. If the patient is currently receiving one drug (ACE inhibitor or ARB) below the maximum labeled dose, the drug should be titrated to the MTLDD based on the assessment of tolerability by the investigator at least 6 weeks prior to the Screen A visit. Diuretics may be titrated to help maintain blood pressure target levels. Any changes in ACE inhibitor or ARB use or diuretic therapy should be preceded by consideration of any relevant contraindications as per the local product information.
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