Nausea and vomiting Sample Clauses

Nausea and vomiting. This may be mild to severe, though it usually improves after the initial days of usage.
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Nausea and vomiting. Grade 1 or 2 nausea (oral intake decreased without significant weight loss, dehydration or malnutrition) OR Grade 1 or 2 vomiting (5 or fewer episodes per day) Any • Maintain selinexor and initiate additional anti-nausea medications. Grade 3 nausea (inadequate oral caloric or fluid intake) OR Grade 3 or higher vomiting (6 or more episodes per day) Any • Interrupt selinexor. • Monitor until nausea or vomiting has resolved to Grade 2 or lower or baseline. • Initiate additional anti-nausea medications for Grade 2 or lower. • Restart selinexor at 1 dose level lower (see Table 4) Diarrhea Grade 2 (increase of 4 to 6 stools per day over baseline) 1st • Maintain selinexor and institute supportive care. 2nd and subsequent • Reduce selinexor by 1 dose level (see Table 4). • Institute supportive care. Grade 3 or higher (increase of 7 stools or more per day over baseline; hospitalization indicated) Any • Interrupt selinexor and institute supportive care. • Monitor until diarrhea resolves to Grade 2 or lower. • Restart selinexor at 1 dose level lower (see Table 4). Weight Loss and Anorexia Weight loss of 10% to less than 20% OR anorexia associated with significant weight loss or malnutrition not due to intensive care status Any • Interrupt selinexor and institute supportive care. • Monitor until weight returns to more than 90% of baseline weight. • Restart selinexor at 1 dose level lower (see Table 4). Other Adverse Reactions Grade 3 or 4 non- hematologic reactions Any • Interrupt selinexor. • Monitor until resolved to Grade 2 or lower, restart selinexor at 1 dose level lower (see Table 4). Life-threatening hematological and non- hematological (Grade 4) AEs related to selinexor Any • Discontinue selinexor a National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0. Only adverse reactions to selinexor should lead to dose adjustments.

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