Protocol Amendments and Study Termination Sample Clauses

Protocol Amendments and Study Termination. If Opthea amends the protocol, agreement from the investigator must be obtained. The IRB / IEC must be informed of all amendments and give approval. Opthea reserves the right to terminate the study at any time either at a particular site or at all sites at any time and for any reason. Both Opthea and the investigator reserve the right to terminate the investigator’s participation in the study according to the study contract. If such action is taken, Opthea will discuss this with the investigator(s) at that time and notify the investigator(s) in writing. If the study is suspended or terminated for safety reasons all investigators conducting the study will be immediately notified of the action as well as the reason for it, as will the relevant regulatory agencies. The Investigator will advise the IRB / IEC overseeing the study at their site. Upon closure of the study (whether at the expected conclusion or prematurely), the following activities will be performed by the Sponsor in conjunction with the Investigator: • Return of all study data • Data clarification and resolution of queries • Study drug accountability, reconciliation and final disposition • Review of site study records for completeness • Shipment of all relevant samples to the central laboratory The investigator should notify the IRB / IEC in writing of the study’s completion or early termination and send a copy of the notification to Opthea.
Sample 1
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Related to Protocol Amendments and Study Termination

  • RENEWAL, AMENDMENT AND TERMINATION (a) This Agreement shall become effective on the date first written above and shall remain in force for a period of two (2) years from such date, and from year to year thereafter but only so long as such continuance is specifically approved at least annually (i) by the vote of a majority of the Trustees who are not interested persons of the Portfolio or the Investment Adviser, cast in person at a meeting called for the purpose of voting on such approval and by a vote of the Board of Trustees or (ii) by the vote of a majority of the outstanding voting securities of the Portfolio. The aforesaid provision that this Agreement may be continued "annually" shall be construed in a manner consistent with the 1940 Act and the rules and regulations thereunder.

  • Appendix B Amendments The following Appendix B clauses are hereby amended as follows:

  • Agreed Amendments The MSAA is amended as follows.

  • Implementation of Agreement Each Party must promptly execute all documents and do all such acts and things as is necessary or desirable to implement and give full effect to the provisions of this Agreement.

  • Execution of Agreement and Effective Date The Agreement shall become effective (i.e., final and binding) upon the date of signing of this Agreement and the CAP by the last signatory (Effective Date).

  • Change Orders and Contract Amendments 33.1 The Procuring Entity may at any time order the Supplier through notice in accordance GCC Clause 8, to make changes within the general scope of the Contract in any one or more of the following:

  • CHANGE ORDERS AND AMENDMENTS A. Any alterations, additions, or deletions to the terms of this Agreement, which are required by changes in federal or state law or by regulations, are automatically incorporated without written amendment hereto, and shall become effective on the date designated by such law or by regulation.

  • Acceptance and Amendments This Agreement shall not become effective until accepted by Tomorrow Energy. Tomorrow Energy may amend the terms of this Agreement at any time, consistent with any applicable law, rule or regulation, by providing notice to Customer of such amendment at least thirty (30) days prior to the effective date thereof. Upon receipt of written notice of a material change, customer may terminate this Agreement prior to the date such change becomes effective without penalty.

  • Effective Date of Agreement The provisions of the agreement will come into full force and effect on the date of ratification, unless specified otherwise.

  • Textual Amendments F10 Clause 3 repealed by Chevening Estate Act 1987 (c. 20, SIF 57), s. 3(1), Sch. 2 para. 6(1)(b)

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