Responsibility for Supply of ASO and Costs for ASO Supply Sample Clauses

Responsibility for Supply of ASO and Costs for ASO Supply. Isis shall be responsible for the manufacture and supply of all ASOs for use in support of the Research Program, and all such manufacture will be performed at Isis’ facilities. Isis shall not use a Third Party (sub)contractor for the manufacture of ASOs without the prior written approval of BMS. Isis shall bear its own costs for the manufacture of up to [***] of each ASO. For quantities in excess of such [***] for any ASO, BMS shall order such additional quantities in [***] increments. Isis will be responsible for the first $[***] cost to manufacture such additional quantities of ASOs in the aggregate, and thereafter, BMS will reimburse Isis for its costs of manufacturing such ASOs (subject to Section 3.5.2(b) above). The cost to manufacture such additional quantities of ASOs will be negotiated and agreed to in good faith by the Parties, but shall not exceed $[***] per gram for MOE Gapmers. As set forth in Section 4.2 and 4.3, Isis shall manufacture and supply API for use in IND-Enabling Studies and for use for clinical Development through completion of Phase IIb Trials, which cost shall not exceed $[***] per gram. All such API manufacture will be performed at Isis’ facilities. Isis shall not use a Third Party (sub)contractor for the manufacture of such API without the prior written approval of BMS.
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Related to Responsibility for Supply of ASO and Costs for ASO Supply

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