Rifampicin loading Sample Clauses

Rifampicin loading. With the increase of rifampicin input from 5 to 25 mg, the drug content in the NS significantly increased from 06.5 ± 0.5 to 22.9 ± 0.5 % (table 3.2). As the loading of rifampicin increased the NS encapsulation efficiency slightly reduced from 38.6 ± 1.1 to 29.3 ± 0.7 %. The drug recovery was significantly lower with low drug input and this correlated with the presence of drug crystal nanosuspensions with a high drug loading. The size of rifampicin-loaded NS ranged from 200 nm to 226 nm. As the drug input increases there was a slight increase from 209 m to 217 nm. The polydispersity index was low for NS batches (PI<0.1) indicating a very narrow size distribution. When the NC drug input increased from 5 to 25 mg, the drug content of the nanocapsules increased from 2.1 ± 0.1 to 8.1 ± 0.5 % (Table 3.2). Rifampicin- loaded NC were significantly smaller than than the placebo samples (p < 0.05, ANOVA). However, as the rifampicin input increase there was not a significant increase (p > 0.05) (Table 3.2). The polydispersity index of the rifampicin-loaded NC ranged between 0.1 and 0.25 but the size distribution was consistently monomodal. Nanoparticles Drug input (mg) Drug content (%) Encapsulation efficiency (%) Drug recovery (%) Particle size (nm) NS-1 NS-2 NS-3 NS-4 NC-1 NC-2 NC-3 5 10 25 50 5 10 25 06.5 ± 0.5 11.7 ± 0.6 22.9 ± 0.5 - 2.1 ± 0.1 3.6 ± 0.1 8.1 ± 0.5 38.6 ± 1.1 34.5 ± 0.5 29.3 ± 0.7 - 39.3 ± 0.5 35.5 ± 0.8 32.3 ± 0.3 73.6 ± 3.1 81.1 ± 0.8 86.2 ± 1.5 - 72.6 ± 0.9 78.5 ± 2.2 85.7 ± 7.4 209.2 ± 4.7 212.1 ± 5.2 217.3 ± 9.9 - 134.6 ± 4.1 132.1 ± 7.7 130.4 ± 5.3
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