State of the Art: Examples Sample Clauses

State of the Art: Examples. To provide an overview of the state of the art in this field, specifically in relation to different organs, information has been assembled into tables presented in Annex 1. The overview presented in Annex 1 underscores that the development of OCs for toxicity testing is still in its infancy. Various models have been developed, but a clear analysis of the requirements from risk assessment are lacking. For this, one needs to be aware where information from OCs has added value or where they can usefully tackle bottlenecks facing current risk assessment processes. In general, three types of models can arguably be useful for toxicity testing through OCs: 1) tissues representing tests under healthy conditions, 2) tissues representing tests under pathological conditions or 3) tissues representing barriers such as the gut wall, blood-brain-barrier, placenta, etc. The relatively long viability of OCs and the dynamic character of OCs may make these systems more suitable to mimic repeated dose experiments than conventional and more static in vitro systems. The feasibility of using OCs for repeated dose experiments, however, is still under investigation.
Sample 1
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