HDAC Inhibitor definition

HDAC Inhibitor means any small molecule that inhibits the activity of histone deacetylase.
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HDAC Inhibitor means [***********************************].
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HDAC Inhibitor means a pharmaceutical product that is an inhibitor of histone deacetylase (HDAC) and developed, produced, manufactured, derived from or would infringe, absent a license or ownership, any of the Intellectual Property owned by or licensed to the Company.
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Examples of HDAC Inhibitor in a sentence

  • For the avoidance of doubt, any HDAC Inhibitor Compound, the rights to which are licensed or otherwise acquired from a Third Party by NIBRI or its Affiliates, shall be considered to be a Prior Clinical NIBRI HDAC Inhibitor Compound if such Third Party (or NIBRI or its Affiliates) has submitted an IND with the FDA and initiated a Phase I Clinical Trial covering such HDAC Inhibitor Compound prior to the date of such license or acquisition.

  • Notwithstanding the foregoing, any In-Licensed NIBRI HDAC Inhibitor Compound shall not be a Collaboration HDAC Inhibitor Compound.

  • Each disclosure hereunder regarding an HDAC Inhibitor shall include the composition of the HDAC Inhibitor and all data with respect thereto in the possession or Control of TOPOTARGET.

  • Upon determination that any such compound is an HDAC Inhibitor, such compound shall be deemed a Compound hereunder, and shall be subject to the terms and conditions of this Agreement.

  • The schedule below corresponds to an identical schedule in the License Agreement for all HDAC Inhibitor Compounds with respect to milestones achieved in the Field; payments made pursuant to this Agreement prior to exercise of an Option shall be treated as payments made under the applicable License Agreement.

  • Furthermore, these authors found that trichostatin A, a selective class I and II mammalian HDAC Inhibitor (Vanhaecke et al.,2004) was capable of inhibiting tubulin deacetylation during platelet stimulation (Sadoul et al., 2012).

  • The JSC will determine the number of FTEs that will be assigned to the HDAC Inhibitor Research Program, which FTEs will be incremental to the minimum FTEs specified in the Research Plan prior to the Amendment Date.

  • Sodium phenylbutyrate, (representative to HDAC Inhibitor) cyclophosphamide, procaine, carboplatin, and temozolomide (representative to DNMT inhibitor chemotherapeutic agents) were all purchased from Santa Cruz Biotechnology (USA).

  • On April 21, 2008, the Company entered into a transfer and termination agreement (the "Transfer Agreement") with TopoTarget to transfer CuraGen's ownership and development rights to belinostat, a Phase I/II HDAC Inhibitor, and any other HDAC Inhibitors.

  • CUDC-907 is a Potent Class I and II HDAC Inhibitor (IC50s in nM) HDACs HDAC1 HDAC2 HDAC3 HDAC8 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10 HDAC11 Compound XXXX 00.0 000 00.0 000 XX XX 00.0 XX XX 68.4 51.3 In line with its intended activity and network-targeted properties, CUDC-907 inhibits markers of HDAC and PI3K inhibition (Figure 2A, reference 39 and data not shown).


More Definitions of HDAC Inhibitor

HDAC Inhibitor means any small molecule that inhibits the activity of histone deacetylase. “Improvements” has the meaning set forth in Section 3.1(b). “Indemnified Party” has the meaning set forth in Section 12.4(a). “Indemnifying Party” has the meaning set forth in Section 12.4(a). “Initial Period” has the meaning set forth in Section 3.4(b). “Inventions” means any new or useful method, process, manufacture, compound or composition of matter, whether or not
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Related to HDAC Inhibitor

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Licensed Compound means [***].

  • Diagnostic Product means any test or assay for diagnosing or detecting a disease, disorder, medical condition, or symptom.

  • Licensed Compounds means: (a) Research Program Active Compounds; (b) Novartis Active Compounds; (c) salts, hydrates, solvates, esters, metabolites, intermediates, stereoisomers and polymorphs of Research Program Active Compounds or Novartis Active Compounds; and (d) prodrugs of Research Program Active Compounds or Novartis Active Compounds (any of the foregoing, a “Licensed Compound”).

  • Antibody means a molecule comprising or containing one or more immunoglobulin variable domains or any fragments, derivatives, variants or modifications thereof that bind to the same antigen.

  • Therapeutic Product means a health product categorised as a therapeutic product in the First Schedule to the Act;

  • Collaboration Target means the Initial Collaboration Targets set forth on Exhibit F and any Additional Target or Substitute Target that is selected in accordance with Section 3.3 of this Agreement.

  • Opioid antagonist means a drug that binds to opioid

  • Corrosion inhibitor means a substance capable of reducing the corrosivity of water toward metal plumbing materials, especially lead and copper, by forming a protective film on the interior surface of those materials.

  • Collaboration Product means a pharmaceutical product containing or comprising Compound in any dosage form alone, or in combination with, one or more other pharmaceutically active ingredients, and any and all Improvements thereto.

  • Biomarker means a parameter or characteristic in a patient or Patient Sample, the measurement of which is useful (a) for purposes of selecting appropriate therapies or patient populations or monitoring disease susceptibility, severity or state, or monitoring therapies for such patient and/or (b) for predicting the outcome of a particular treatment of such patient.

  • Biological product means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, protein other than a chemically synthesized polypeptide, or analogous product, or arsphenamine or any derivative of arsphenamine or any other trivalent organic arsenic compound, applicable to the prevention, treatment, or cure of a disease or condition of human beings.

  • Lead Compound means any compound of lead other than galena which, when treated in the manner described below, yields to an aqueous solution of hydrochloric acid a quantity soluble lead compound exceeding, when calculated as lead monoxide, five percent of the dry weight of the portion taken analysis.

  • Gene Therapy means the introduction of a nucleic acid sequence encoding a protein intended for or otherwise conferring therapeutic benefit into a person for therapeutic purposes (i) by in vivo introduction for incorporation into cells of such person, or (ii) by ex vivo introduction into cells for transfer into a person.

  • Receptor means enclosed spaces, conduits, protected groundwater sources, drinking and non-drinking water wells, surface water bodies, and public water systems which when impacted by chemicals of concern may result in exposure to humans and aquatic life, explosive conditions or other adverse effects on health, safety and the environment as specified in these rules.

  • Licensed Product means a product or part of a product in the Licensed Field of Use: (A) the making, using, importing or selling of which, absent this license, infringes, induces infringement, or contributes to infringement of a Licensed Patent; or (B) which is made with, uses or incorporates any Technology.

  • Nicotine product means a product that contains nicotine and is not any of the following:

  • Compounds means any or all of the following chemicals, as the context requires:

  • Exempt compound means the same as defined in Rule 2.

  • Product Candidate means any pharmaceutical product developed, manufactured and/or tested by or on behalf of the Company that has not received a Regulatory Authorization for commercial distribution other than in connection with pre-clinical or clinical trials.

  • Therapeutic school means a residential group living facility:

  • Compound means the taking of two or more ingredients and fabricating them into a single

  • Commercialized shall have corresponding meanings.

  • Back-Up Compound means, with reference to any particular Development Candidate or Drug Product Candidate, a Compound which (a) has the same principal mode of action (i.e., Potentiator or Corrector) as that Development Candidate or Drug Product Candidate; and (b) was among the group of Compounds, identified by VERTEX as potential additional lead molecules having the same principal mode of action, from which the Development Candidate was selected.

  • Biological Samples means any physical samples obtained from Study Participants in accordance with the Protocol for the purposes of the Study.

  • Development Candidate means a Compound that meets the Development Candidate Criteria for the initiation of a Development Program for the treatment of CF, and which is the subject of a notice from Vertex to CFFT that Vertex intends to commence formal pre-clinical development of the Compound in the Field pursuant to the provisions of Section 3.1 hereof.