Orphan Receptor definition

Orphan Receptor means a G Protein Coupled Receptor that is not constitutively active and for which the Endogenous ligand is not publicly known.
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Orphan Receptor means all species of any of (i) the *** *** receptors, and (ii) any orphan receptor discovered by Ligand prior to the expiration of the Ligand Option.
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Orphan Receptor means a GPCR lacking any identified Known Ligand.
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Examples of Orphan Receptor in a sentence

  • In the event that Arena does provide such Notice to Fujisawa and Fujisawa does not provide Notice to Arena within such twenty-one (21) day period, Fujisawa shall be deemed to have understood the rights of Arena to exercise its ownership interests in and to such Arena ************** Orphan Receptor, and all data related thereto, whether developed by Arena or Fujisawa.

  • In the event that the Arena Antisense Oligonucleotide meets the Cooperative Efficacy Criteria, then the Parties acknowledge and agree that the provisions of Article III shall automatically begin with respect to the Arena ************** Orphan Receptor corresponding to such Arena Antisense Oligonucleotide.

  • Calcium Signaling via Orai1 Is Essential for Induction of the Nuclear Orphan Receptor Pathway To Drive Th17 Differentiation.

  • The Parties further acknowledge and agree that after the Effective Date, if the Endogenous ligand for any Arena ************** Orphan Receptor is discovered, then such non-orphan receptor shall continue to be treated as an Arena ************** Orphan Receptor for purposes of this Agreement.

  • The Parties further acknowledge and agree that in the event that a Third Party wishes to secure rights to any Arena ************** Orphan Receptor, Arena shall provide Notice to Fujisawa informing Fujisawa of such Third Party interest together with documentation evidencing such Third Party interest; Fujisawa shall thereafter have twenty-one (21) days to provide Notice to Arena as to whether Fujisawa shall exercise the provisions of Section 2.6 of this Agreement.

  • Unless otherwise specified as contemplated by Section 301, the Securities of each series shall be issuable in registered form without coupons.

  • Another member of the orphan receptor family of TFs, Retinoic Acid related Orphan Receptor alpha (ROR!), regulates Th17 cell lineage by synergistic co-operation with ROR#t (173).

  • Quantitative Real-time PCR was carried out for four selected genes: hypoxia-inducible factor- 1A (HIF-1A), Retinoic Acid Receptor-Related Orphan Receptor C (RORC), natural cytotoxicity receptor (NCR1), and Interleukin 1 receptor-like 1 (IL1RL1).

  • C7, RPKean BA'78ElementaryAIDES (Para/lunch aides) Jessica Knierim5A Sheridan Ave., RP Martha Stephens314 W.

  • The Company’s clinical pipeline consists of its lead program, cirmtuzumab, a humanized monoclonal antibody that binds to ROR1 (Receptor-tyrosine kinase-like Orphan Receptor 1), and TK216, a small molecule inhibiting the biological activity of ETS-family transcription factor oncoproteins targeting patients with Ewing sarcoma.

Related to Orphan Receptor

  • Receptor means enclosed spaces, conduits, protected groundwater sources, drinking and non-drinking water wells, surface water bodies, and public water systems which when impacted by chemicals of concern may result in exposure to humans and aquatic life, explosive conditions or other adverse effects on health, safety and the environment as specified in these rules.

  • Antibody means a molecule comprising or containing one or more immunoglobulin variable domains or any fragments, derivatives, variants or modifications thereof that bind to the same antigen.

  • Opioid antagonist means a drug that binds to opioid

  • Antigen means a substance recognized by the body as being foreign; it results in the production of specific antibodies directed against it.

  • Preceptor means an individual who provides, directs, or verifies training and experience required for an individual to become an authorized user, an authorized medical physicist, an authorized nuclear pharmacist, or a radiation safety officer.

  • Vaccine means a specially prepared antigen which, upon administration to a person, will result in immunity and, specifically for the purposes of this rule, shall mean influenza and pneumococcal vaccines.

  • HIV means human immunodeficiency virus.

  • Therapeutic school means a residential group living facility:

  • coronavirus means severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);

  • Collaboration Compound means any of the following: (a) FG-4592, (b) any HIF Compound (other than FG-4592) that is added to this Agreement pursuant to Section 3.6, and (c) any salts, esters, complexes, chelates, crystalline and amorphous morphic forms, pegylated forms, enantiomers (excluding regioisomers), prodrugs, solvates, metabolites and catabolites of any of the foregoing ((a) or (b)).

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • Biological diversity means the variability among living organisms from all sources including, inter alia, terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; this includes diversity within species, between species and of ecosystems.

  • Collaboration Technology means all Collaboration Patents and Collaboration Know-How.

  • Diagnostic Product means any test or assay for diagnosing or detecting a disease, disorder, medical condition, or symptom.

  • Biomarker means a parameter or characteristic in a patient or Patient Sample, the measurement of which is useful (a) for purposes of selecting appropriate therapies or patient populations or monitoring disease susceptibility, severity or state, or monitoring therapies for such patient and/or (b) for predicting the outcome of a particular treatment of such patient.

  • Therapeutic Product means a health product categorised as a therapeutic product in the First Schedule to the Act;

  • Massive Multiauthor Collaboration Site (or “MMC Site”) means any World Wide Web server that publishes copyrightable works and also provides prominent facilities for anybody to edit those works. A public wiki that anybody can edit is an example of such a server. A “Massive Multiauthor Collaboration” (or “MMC”) contained in the site means any set of copyrightable works thus published on the MMC site.

  • haemophilia means an inheritable disease, usually affecting only male but transmitted by women to their male children, characterised by loss or impairment of the normal clotting ability of blood so that a minor would may result in fatal bleeding;

  • genocide means any of the following acts committed with intent to destroy, in whole or in part, a national, ethnical, racial or religious group, as such:

  • Pharmacist preceptor or “preceptor” means a pharmacist licensed to practice pharmacy whose license is current and in good standing. Preceptors shall meet the conditions and requirements of rule 657—4.9(155A). No pharmacist shall serve as a preceptor while the pharmacist’s license to practice pharmacy is the subject of disciplinary sanction by a pharmacist licensing authority.

  • Opioid means a drug that produces an agonist effect on opioid receptors and is indicated or used for the treatment of pain.

  • Therapeutic diet means meals served that are soft, low-fat, low-sodium or controlled calorie.

  • Collaborative drug therapy management means participation by an authorized pharmacist and a physician in the management of drug therapy pursuant to a written community practice protocol or a written hospital practice protocol.

  • Biological Samples means any physical samples obtained from Study Participants in accordance with the Protocol for the purposes of the Study.

  • Anabolic steroid means any drug or hormonal substance, chemically and pharmacologically related

  • Medical marijuana product means a product that contains cannabinoids that have been extracted from plant material or the resin therefrom by physical or chemical means and is intended for administration to a licensed patient, including but not limited to concentrates, oils, tinctures, edibles, pills, topical forms, gels, creams, and other derivative forms, except that this term does not include live plant forms.