Please definition

Please email this Put Notice to: gxxxxxxxxxxxxxxxxx@xx.xx

Please sign the enclosed counterpart of this Amendment in the space provided below, whereupon this Amendment, upon acceptance by Lender, shall become a binding agreement by and between Borrower and Lender.

Please confirm that the foregoing is in accordance with your understanding by indicating your acceptance hereof at the place below indicated, whereupon it shall become a binding agreement between us.

More Definitions of Please

Please sign this Agreement and return one signed original copy to me, acknowledging your agreement with and acceptance of these terms of employment. Sincerely, RIBOZYME PHARMACEUTICALS, INC. By: /s/ Howard W. Robin ---------------------------- Name: Howard W. Robin Title: President xxx Xxxxf Xxxxutive Officer Agreed and accepted: /s/ Marvin Tancer ---------------------------- Marvin Tancer Xxxxx: February 11, 2003 Acknowledged anx xxxxxx: OXFORD BIOSCIENCE PARTNERS IV L.P. By: /s/ Alan Walton ----------------------- Name: Alan Waltxx Title: General Partner THE SPROUT GROUP Xx: /x/ Philippe O. Chambon ------------------------- Name: Xxxxxxxx X. Xxxxxxn Title: Managing Director VENROCK XXXXXXXXXX Xx: /s/ Bryan Roberts ------------------------ Name: Bryax Xxxxxxx Title: As a General Partner or Member

Please. PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE OF ASSIGNEE the within Series E Senior Note and all rights thereunder, hereby irrevocably constituting and appointing . . . . . . agent to transfer said Series E Senior Note on the books of the Company, with full power of substitution in the premises. Dated: ,

Please sign this Agreement and return one signed original copy to me, acknowledging your agreement with and acceptance of these terms of employment. Sincerely, RIBOZYME PHARMACEUTICALS, INC. By:________________________________ Name: Title: Agreed and accepted: __________________________ Marvin Tancer Dated: February ____, 2003 Acxxxxxxxxxx xxd agreed: OXFORD BIOSCIENCE PARTNERS IV L.P. By:_________________________ Name: Title: THE SPROUT GROUP By:_________________________ Name: Title: VENROCK ASSOCIATES By:_________________________ Name: Title:

Please file in Compensation Section 7, of the DR Planner THIS PAGE IS INTENTIONALLY BLANK SCHEDULE OF COMMISSION RATES TABLE OF CONTENTS Cover Page and Table of Contents EXHIBIT I: I Payment Provisions

Please sign below to indicate your acknowledgement of receipt of this letter and your agreement to its terms. IHE FUNDING CORP. By:_________________________________ Name: Xxxxxxx X. Xxxxxxxx Title: Vice President and Treasurer ACKNOWLEDGED AND AGREED: THE CHASE MANHATTAN BANK By:________________________________ Name: Xxxxxx Xxxxxxxxx Title: Vice President Date: November 18, 1997 November 18, 0000 Xxx Xxxxx Xxxxxxxxx Bank 000 Xxxx 00xx Xxxxxx Xxx Xxxx, Xxx Xxxx 00000 Attention: Xxxxxx Xxxxxxxxx Global Trust Services Re: Pooling and Servicing Agreement (the "Agreement"), Mortgage Loan Certificates, Series 1997-2, and Class R and Additional Certificates, dated as of November 1, 1997 among Prudential Securities Secured Financing Corporation, Xxxxx Home Equity Corporation and The Chase Manhattan Bank (the "Trustee"), as Trustee Dear Xx. Xxxxxxxxx: The undersigned, the Holders of the Class R Certificates issued under the above-captioned Agreement, do hereby direct the Trustee, pursuant to Section 6.12 of the Agreement, and for so long as the Capitalized Interest Account is required to be maintained, to accept for deposit in the Capitalized Interest Account, as a Permitted Investment, a letter of credit (the "Letter of Credit") issued by The Northern Trust Company (the "L/C Issuer"), dated as of November 17, 1997, in the favor of The Chase Manhattan Bank, as Trustee of the Xxxxx Home Equity Corporation Trust 1997-2. Capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement. With respect to the Letter of Credit, we hereby instruct the Trustee as follows:

Please sign below to indicate your acknowledgement of receipt of this letter and your agreement to its terms. XXXXX HOME EQUITY CORPORATION, as Servicer By:_____________________________ Name: Xxxxx Xxxxxx Title: Vice President - Finance and Servicing ACKNOWLEDGED AND AGREED: THE CHASE MANHATTAN BANK By:________________________________ Name: Xxxxxx Xxxxxxxxx Title: Vice President Date: November 18, 0000 Xxx Xxxxx Xxxxxxxxx Bank 000 Xxxx 00xx Xxxxxx Xxx Xxxx, Xxx Xxxx 00000 Attention: Xxxxxx Xxxxxxxxx Global Trust Services Re: Pooling and Servicing Agreement (the "Agreement"), Mortgage Loan Certificates, Series 1997-2, Class A and Class R and Additional Certificates, dated as of November 1, 1997 among Prudential Securities Secured Financing Corporation, Xxxxx Home Equity Corporation and The Chase Manhattan Bank (the "Trustee"), as Trustee Dear Xx. Xxxxxxxxx:

Please and "thank you" to the people who serve you, cleaning up after yourself, and observing generally accepted rules of