Cytokines and growth factors Sample Clauses

Cytokines and growth factors. Evidence exists that the effectors of ovarian steroids in fibroid growth includes locally produced cytokines and growth factors. Investigators have shown a higher concentration of TGF - β3 in fibroids, which is thought to promote cell proliferation and extracellular matrix formation, compared to autologous myometrium. The concentration of TGF - β3 increased in the secretory phase of the cycle which suggests it is modulated by progesterone (Arici et al. 2000). EGF is found in similar levels in fibroids and myometrium but in contrast to myometrium, in fibroids the levels of EGF increase after exposure to progesterone (Xxxxxxxx-Xxxxxxxx et al. 1994; Xxxxx et al. 2000). The level of EGF receptors in fibroids however display greater sensitivity to regulation by ovarian sex hormones than EGF receptors in myometrium as evidenced by the reduction of EGF receptors in fibroids of women treated with GnRH analogues. In fact the reduction of EGF receptors correlates with the shrinkage of fibroids suggesting that the ovarian sex hormone effect of GnRH analogues is partly mediated by EGF (Xxxxx et al. 2003).
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