Description of the work carried out A first proposal for general Technical Guideline and associated SOPs for identification and quantification of chemical surface modifications MNM has been established. The guideline and SOPs is intended to be proposed by XXXxXXX as a future work item for the OECD Working Party on MNM. The Technical Guideline consists of an initial screening procedure using relatively simple methods to first identify MNM, which may have been chemically modified by doping and/or surface coating and/or functionalization, which is then followed by more advanced analysis using different proposed SOPs depending on the type(s) of possible modifications observed . The Technical Guideline is primarily described for analysis of unknown MNM, however, the SOPs can naturally also be applied for quality control and quantification of chemical modifications and surface coatings of MNM with known chemical modifications. In such cases the low-cost simpler screening procedures could be sufficient to identify and quantify the chemical modifications of the MNM. Even-though it was attempted several times, the Technical Guideline and associated SOPs have not been subject to interlaboraty comparisons or full internal validation. The NANoREG core MNM does not include a sufficient number and variety of chemically modified MNM to allow validation. Therefore, further work should involve testing of the proposed Technical Guideline and SOPs, interlaboratory comparison studies, and validation after SOP revisions as required.
Description of the work carried out As a first step, a literature review has been performed by LNE (Partner 47). From this 75-page report, recommendations for characterizing and monitoring test aerosols through inhalation studies are made (Figure 3). As a second step, experimental works have been performed by four partners (4, 21, 37 and 47) in order to characterize different test aerosols using different generation methods to be used for inhalation studies. During this second step, some of the experiments have been conducted onto inhalation facilities.
Description of the work carried out The report is structured in two parts that reflect the work carried out towards the two different objectives. Part 1 includes the work carried out to fulfil Objective One: Evaluate existing qualitative and semi- quantitative tools (such as control banding tools). In Section 2.3.1, a summary of the different available tools is provided, in terms of their applicability domain, assumptions made, inputs required and outputs provided is required.
Description of the work carried out The selected case studies aim to consider different parts of the value chain (see Fig.2 in D1.6 for a description of the NANoREG SVCCS approach), since no case study was available representing the whole process, from design, over production/manufacturing, to use and disposal/recycling. The establishment of SVCCSs and evaluation of their outcome was done in close cooperation with XXXxXXX WPs performing experimental work. This deliverable D1.7 aims to report on the background to, progress with, results of and conclusions from SVCCSs that are or have been performed within the NANOREG Project. In addition, the D1.7 provides information and conclusions regarding: - Uncertainties with respect to safety issues of investigated NMs and nano-enabled products, - Risk-reduction strategies, - The impact of such strategies for existing and future risk potentials for humans and the environment (EHS).
Description of the work carried out This deliverable is based on a review of the existing and emerging ECHA Guidance for substance identification, grouping, QSAR and read-across. The review was focused on a number of issues:
