Homologous mechanisms of familial and sporadic Sample Clauses

Homologous mechanisms of familial and sporadic. PD Mutations of the above-mentioned genes constitute the bulk of the causative agents in familial PD. The intense study of these genes and their involvement in PD has not only led to a greater understanding of the genetic cases of PD but has also shed light on the potential mechanisms of sporadic cases. For example, α-synuclein accumulation into LBs is also a prevalent feature of sporadic PD, despite a lack of SNCA mutations (Xxxx et al. 2008). In addition, the LRRK2, xxxxxx and PINK1 mutation phenotypes all show great similarity to sporadic PD (Xxx et al. 2004, Xxxxxx & Xxxxx 2009, Xxxxxx & Xxxxx 2012). In particular, the mitochondrial defects caused by mutations in these genes have resulted in a significant amount of research being carried out to investigate the relationship between the mitochondria and PD.
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