Hypoxia/ Ischemia Sample Clauses

Hypoxia/ Ischemia. Definitions and Considerations A constant supply of oxygen is required for normal cellular metabolism. Hypoxia manifests in a number of disease states such as; coronary artery disease, acute myocardial infarction [2-3], stroke [4], certain types of cancer [5], rheumatoid arthritis [6] and diabetic vasculopathies [7]. Hypoxia may also be present in diseases where oxygen tensions are likely to be reduced due to poor respiratory function, e.g. cystic fibrosis and chronic bronchitis, sleep apnoea [8], epilepsy [9-10], as well as in benign proliferative diseases like psoriasis. Hypoxia is defined as a disparity between oxygen availability and the amount required by a biological system to function optimally, and may be subdivided into two categories; supply hypoxia and demand hypoxia. Supply hypoxia is a condition that is caused by an inadequate supply of oxygen. Demand hypoxia on the other hand arises when cellular energy consumption increases, for example during exercise, without a concomitant increase in oxygen delivery. Ischaemia, like hypoxia, is also defined as a disparity between supply and demand, but refers specifically to blood. Ischaemia is therefore a more complex situation than hypoxia in that blood not only transports oxygen, nutrients and signalling molecules, but also removes metabolic waste produces (e.g. lactate). The accumulation of waste metabolites due to low blood flow can have a detrimental effect on cellular function, and may compromise cellular integrity and viability. While hypoxia is therefore an intrinsic element of ischaemia, the latter is a more complex multifaceted condition.
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Related to Hypoxia/ Ischemia

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  • Influenza Vaccination The parties agree that influenza vaccinations may be beneficial for patients and employees. Upon a recommendation pertaining to a facility or a specifically designated area(s) thereof from the Medical Officer of Health or in compliance with applicable provincial legislation, the following rules will apply:

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  • Publikace a) The Institution and the Investigator agree that the Sponsor shall have the sole and exclusive right to the first publication of the results of the Study. Such Sponsor publication is intended to be a multi-center publication of the Study results, collected from all investigators and institutions participating in the Study (the “Multi- Center Publication”). If the Investigator is interested in contributing to or participating in the Multi-Center Publication, he or she must contact the Sponsor. Selection of authors/participants will be governed by the Sponsor, considering individuals’ contribution to the Study.

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