Coronary Artery Disease Sample Clauses

Coronary Artery Disease. The first evidence of narrowing of the lumen of at least one coronary artery by a minimum of 75% and of two others by a minimum of 60%, regardless of whether or not any form of coronary artery Surgery has been performed. Coronary arteries herein refer to left main stem, left anterior descending circumflex and right coronary artery and not its branches which is evidenced by the following a. evidence of ischemia on Stress ECG (NYHA Class III symptoms) b. coronary arteriography (Hearth Cath)
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Coronary Artery Disease. Coronary artery disease (CAD) is caused by the formation and growth of atherosclerotic plaques within the walls and lumen of the coronary arteries [11]. This is a chronic process, and it may take many years for the pathophysiological consequences of CAD to manifest into clinical symptoms [12]. Progressive narrowing of the coronary arteries compromises the supply of blood to the affected region of the heart, initially causing demand ischaemia. The supply of blood is inversely correlated to the severity of the occlusion, and while sufficient nutrients may be delivered to the affected region when the sufferer is at rest, as the demand for energy substrates and oxygen increases, such as during exercise (or in severe cases by simply walking or even standing), perfusion may fail to meet the requirements of the contracting myocardium. The repercussion of this is the manifestation of angina pectoris (chest pain) [11]. CAD is associated with stable angina, whereby the symptoms usually xxxxx within a few minutes of resting. While angina may be discomforting and painful to the sufferer, it is not necessarily life threatening. However other complications that may coincide or arise as result of CAD are considerably more serious, and may be life threatening. Coronary artery spasm (CAS) may occur in the presence or absence of stenosis, and can alone be a cause of cardiac ischaemia [13]. However when CAS occurs in conjunction with CAD, it is more likely to lead to complete occlusion of the effected artery/s, which will then starve the myocardium of blood, and lead to myocardial infarction (heart attack).
Coronary Artery Disease. The last few decades have witnessed a considerable transition in the epidemiology of disease in low- and middle-income countries. Increasing urbanization and changing lifestyles have triggered an exponential rise in the frequency of coronary artery disease (CAD) risk factors in black Africans (MOH, 2015). An acute myocardial infarct (AMI) is the most serious presentation of coronary artery disease (CAD) and is associated with serious morbidity and high mortality. It is estimated that half of all patients suffering from an AMI die before arrival to hospital. An ST elevation myocardial infarction (STEMI) occurs when there is an abrupt and complete occlusion of a coronary artery by cholesterol plaques and superimposed thrombus. This starves the heart muscle cells of nutrients and oxygen, leading to cell death and an array of complications. Successful management of an AMI in the early phase is time sensitive and requires recognition of symptoms, prompt diagnosis by ECG and urgent institution of treatment aimed at restoring blood flow in the blocked artery. Rapid transfer to a hospital capable of providing this treatment and early management of complications such as cardiac arrest are key determinants of success. In 2005, coronary artery disease caused approximately 361,000 deaths in the African region, and current projections suggest that this number will nearly double by 2030 (Mathers CD and Xxxxxx D, 2006). Importantly, in people aged under 60 years, CAD has emerged the leading cause of death in men and the second leading cause of death in women in the African region. Considering that CAD was previously regarded as a rare disease in sub- Saharan Africa, these observations highlight the emerging burden of chronic non-communicable diseases (NCDs) that is now superimposed on the huge burden of infectious diseases, malnutrition, and social conflict that constitute Africa’s health challenges today (Mathers CD and Xxxxxx D, 2006). Traditionally, healthcare systems in sub-Saharan Africa (SSA) were designed to manage communicable and infectious diseases and are not optimally equipped to deal with the rising prevalence of NCDs (Xxxxxxxx J, 2012). According to epidemiological data from the past decade, Kenya has experienced a steep rise in disease burden from cardiovascular diseases. These now account for 6.1 to 8% of all mortality while autopsy studies suggest that 13% of all-cause specific deaths among adults is due to CVD (World Health Organization, 2018). Heart at...
Coronary Artery Disease. The narrowing of the lumen of at least one coronary artery by a minimum of 75% and of two others by a minimum of 60%, as proven by coronary arteriography, regardless of whether or not any form of coronary artery Surgery has been performed. Coronary arteries herein refer to left main stem, left anterior descending circumflex and right coronary artery.
Coronary Artery Disease. The last few decades have witnessed a considerable trathnesietipoindeinmiologoyf disease ilnow- and middle-incomecountries.Increasing urbanization and changing lifsehsatyvle triggered an exponential rise in the frequency of coronary artery disease (CAD) risk factors in bla(cMk OAHfri,c2a0n1s5. ) An acute myocardial infarct (AMI) is the most serious prensoefnctaotrionary artery disease (CAD) and is associated with serious morbidityhaignhdmortality. It is estimated that half of all patients suffering from an AMI die before arrival to hospital. An ST elevation myocardial infarction (STEMI) occurs when thereis an abrupt and complete occlusion of a coronary artery by cholesterol plaques and superimpose thrombus. This starves the heart muscle cells of nutrients and oxygen, leading to cell death and an arra of complications. Successful management of an AMthIeinearly phase is time sensitive and requires recognition of symptoms, prompt diagnosis by ECG and urgent institution of treatment aimed at restoring blood flow in the blocked artery. Rapid transfer to a hospital capable of providing this treatmrleynt and ea management of complications such as cardiac arrest are key determinants of success. In 2005, coronary artery disease caused approximately 361,000 deaths in the African region, and curre projections suggest that this number will nearly double b(yM2a0th3e0rs CDandLoncar D, 2006.) Importantly, in people aged under 60 years, CAD has emerged the leading cause of death in men an the second leading cause of death in women in the African region. Considering that CAD was previous regarded aasrarediseasein sub- Saharan Africa, these observations highlight the emerging burden of chronic no-ncommunicable diseases (NCDs) that is now superimposed on the huge burden of infectious µºÄ¶²Ä¶Äʁ ¾²½¿ÆÅúźÀ¿ʁ ²¿µ chÄaÀlle´ngºes²to½da( My´athÀe¿rs ·CD½º´Å Å andLoncar D, 2006.) Traditionally, healthcare systems in-Ssauhbaran Africa (SSwAe)redesigned to manage communicable and infectious diseases and are not optimally equipped to deal with the rising prevalence of NCD (Shavadia, J2012.) According to epidemiological data from the past decade, Kenya has experienced a steep rise in disease dbeunr from cardiovascular diseases. These now account for 6.1 to 8% of all mortality while autopsy studies suggest that 13-%caoufsaellspecific deaths among adults is due to CVD (World Health Organizat,io2n018). Heart attack management in Kenya facjeosr cmhallengetshat includelimitedcapacityof hea...

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