Ivabradine Sample Clauses

Ivabradine. Ivabradine (IVA) is a novel, specific, heart rate (HR)-lowering agent that acts in sinoatrial node (SAN) cells by selectively inhibiting the pacemaker If current in a dose-dependent manner by slowing the diastolic depolarization slope of SAN cells, and reducing HR at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction121. It has been shown to be non-inferior to B-Blockers122 or calcium antagonists123 in HR reduction. Xxxxxxx Xxxxxxxxxx has a role beyond mere heart rate reduction is still a matter of focused scientific research.
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Ivabradine. Ivabradine (Procoralan, Les Laboratories Servier, France; also available under the following names: Coralan, Corlentor, and Coraxan) has been established as an effective treatment to prevent myocardial ischemia in patients with chronic stable angina122, 189, 190, and recent subgroup analysis raised the hypothesis that ivabradine may be helpful to reduce major cardiovascular events26, 191. This constituted the rationale for an ongoing study, Study assess- InG the morbidity–mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIfY), which will assess the effects of ivabradine in terms of CV morbidity and mortality192. It has been found as well, that ivabradine therapy on top of commonly used dosage of B-Blocker therapy had an additional efficacy with no untoward effect on safety or tolerability193. In the recently published results of the SHIFT randomized placebo-controlled study (Iv- abradine and outcomes in chronic heart failure)194, it was found that in patients allocated to ivabradine , the relative risk of the primary end-point (cardiovascular death or hospital admission for worsening heart failure) dropped by 18% compared to placebo, supporting the importance of heart rate reduction with ivabradine for improvement of clinical outcomes in heart failure patients. Pre-clinical animal studies have shown that ivabradine effect might extend beyond heart rate reduction. It was associated with decreased vascular oxidative stress, improved endothelial fuction and reduced atherosclerotic plaque formation195. This has stimulated further research with a planned phase IV RCT, to assess the effect of ivabradine therapy on reducing inflam- matory markers in patients with acute coronary syndromes195, 196.

Related to Ivabradine

  • Millwright Xxxxx be to assist and work under the direction and instructions I or A. He will work alone at times performing assignments in keeping with his training. During the course of his year, training must become proficient in good practices in the areas of fitting, aligning, lubricating and the operation of all shop tools and machines. In addition to the foregoing, he will be exposed to and the process of learning techniques required in trouble shooting key production machinery, pipe fitting, basic welding and machining but not be expected to display a high degree of proficiency in these areas at this point. Millwright Must be capable of performing the tasks of fittings, aligning, lubricating an able to operate all shop tools and machines. Must under direction become proficient in basic welding and pipe fitting as well as dismantling and reassembly of plant equipment. Under direction,will continueto develop skills in trouble shooting all plant equipment and improve his skills at machining part and be exposed to basic principles of hydraulics and pneumatic. He may work alone frequently, but occasionally will require direction and instructions form Millwright I or A. Millwright 11: be capable, without direction of fitting, aligning and lubrication and taking apart and reassembling plant equipment. In addition, is expected to be able to weld, operate shop tools and do pipe fitting as required. Must under direction, become proficient at effective methods of trouble shooting and repairing hydraulic, pneumatic and mechanical faults in plant machinery. I: Must be capable without direction of performing all practices under Xxxxxxxxxx Must under directionbecomeproficient at reading and understanding blueprints, all phases of installing new equipment, laying out hydraulic and mechanical drives and meet speed and power requirements correctly. Xxxxxxxxxx "A": Must he capable without direction, of performing all under Xxxxxxxxxx X, and Must take full responsibility for work done by himself or his assistant. Must he in possession of a Millwright Certificate or a Machinist Certificate or Welder Certificate. Millwrightspresently employed in this classification will not be required to have a Certificate.

  • meminta nasihat daripada Pihak Xxxxxx dalam semua perkara berkenaan dengan jualan lelongan, termasuk Syarat-syarat Jualan (iii) membuat carian Hakmilik Xxxxx xxxxxx rasmi di Pejabat Tanah xxx/atau xxxx-xxxx Pihak-pihak Berkuasa yang berkenaan xxx (iv) membuat pertanyaan dengan Pihak Berkuasa yang berkenaan samada jualan ini terbuka kepada semua bangsa atau kaum Bumiputra Warganegara Malaysia sahaja atau melayu sahaja xxx juga mengenai persetujuan untuk jualan ini sebelum jualan lelong.Penawar yang berjaya (“Pembeli”) dikehendaki dengan segera memohon xxx mendapatkan kebenaran pindahmilik (jika ada) daripada Pihak Pemaju xxx/atau Pihak Tuanpunya xxx/atau Pihak Berkuasa Negeri atau badan-badan berkenaan (v) memeriksa xxx memastikan samada jualan ini dikenakan cukai. BUTIR-BUTIR HARTANAH : HAKMILIK : Hakmilik strata bagi hartanah ini masih belum dikeluarkan oleh pihak berkuasa. NO. HAKMILIK INDUK / NO. LOT : Geran 203771, Lot 106 Seksyen 3 PEKAN/DAERAH/NEGERI : Pekan Batu Tiga / Petaling / Selangor Darul Ehsan PEGANGAN : Selama-lamanya KELUASAN LANTAI : 93.65 meter persegi (1,008 kaki persegi) PEMAJU : Shanghai Realty (M) Sdn Bhd (350799-U) XXXXXXXX XXX : Xxxxxxxx Xxxxx Bin Xxxxxx BEBANAN : Diserahhak kepada RHB Islamic Bank Berhad (200501003283/680329-V) LOKASI XXX PERIHAL HARTANAH Hartanah tersebut terletak di Pangsapuri Indahria, Xx. 0, Xxxxx Xxxx Xxxx-Xxxxxx Xxxxx, Xxxxx Xxxxxxx, Xxxxxxx 00, 00000 Xxxx Xxxx, Xxxxxxxx Xxxxx Xxxxx. Hartanah tersebut adalah sebuah unit pangsapuri dikenali sebagai Xxxxx Pemaju No. P5-2-11, Tingkat No. 2, Bangunan No. P5, berserta dengan Xxxxx Aksesori No. GRD-07, Pangsapuri Indahria xxx mempunyai alamat surat-menyurat di Unit No. P5-02-11, Pangsapuri Indahria, Xx. 0, Xxxxx Xxxx Xxxx-Xxxxxx Xxxxx, Xxxxx Xxxxxxx, Xxxxxxx 00, 00000 Xxxx Xxxx, Xxxxxxxx Xxxxx Xxxxx. HARGA RIZAB: Harta ini dijual “keadaan seperti mana sediada” dengan harga rizab sebanyak RM 270,000.00 (RINGGIT MALAYSIA: DUA RATUS XXX TUJUH PULUH RIBU SAHAJA) xxx tertakluk kepada syarat-syarat Jualan xxx melalui penyerahan hakkan dari Pemegang Serahak, tertakluk kepada kelulusan di perolehi oleh pihak Pembeli daripada pihak berkuasa, jika ada, termasuk semua terma, syarat xxx perjanjian yang dikenakan xxx mungkin dikenakan oleh Pihak Berkuasa yang berkenaan. Pembeli bertanggungjawab sepenuhnya untuk memperolehi xxx mematuhi syarat- syarat berkenaan daripada Pihak Berkuasa yang berkenaan, jika ada xxx semua xxx xxx perbelanjaan ditanggung xxx dibayar oleh Xxxxx Xxxxxxx.Pembeli atas talian (online) juga tertakluk kepada terma-terma xxx syarat-syarat terkandung dalam xxx.xxxxxxxxxxxxxxxx.xxx Pembeli yang berminat adalah dikehendaki mendeposit kepada Pelelong 10% daripada harga rizab dalam bentuk Bank Draf atau Cashier’s Order di atas nama RHB Islamic Bank Berhad sebelum lelongan awam xxx xxxx xxxx xxxxxx bersama-sama dengan segala cukai jualan xxx perkhidmatan (SST) xxx/atau cukai yang menggantikan SST hendaklah dibayar dalam tempoh sembilan puluh (90) hari dari tarikh lelongan kepada RHB Islamic Bank Berhad melalui XXXXXX. Butir-butir pembayaran melalui XXXXXX, xxxx berhubung dengan Tetuan T. Rajagopalu & Co. Untuk maklumat lanjut, xxxx berhubung dengan TETUAN T. RAJAGOPALU & CO, Solicitors for Assignee herein whose address is at Xxxxx 0-0, Xxxxxxxx Xxxx Xxxxxx Xxxxx Xxxxx, 00000 Xxxxxxxx Xxxxxx Xxxxxxxx. Tel: 00-0000000 / Fax: 00-0000000 [Ruj: RG/RHB/0339/2023/SYAFIQAH(yusof)], peguamcara bagi pihak pemegang xxxxx xxx atau pelelong yang tersebut dibawah. RAJAN AUCTIONEERS SDN. BHD. X. XXXXX Xx.00X,Xxxxxxx Xxxx,Xxxxx Xxxx Xxxxxx, ( Xxxxxxxx Berlesen ) 41000 Klang, Selangor Darul Ehsan. H/P: 000-0000000 Tel: 00-00000000 / Fax : 00-00000000 H/P: 012-2738109 Ruj Kami: RA/RHBI/TRC/NS/4220-24(fz) CONDITIONS OF SALE

  • Povinnosti Zkoušejícího Investigator is responsible for the conduct of the Study at Institution. In particular, but without limitation, it is the Investigator’s duty to review and understand the information in the Investigator’s Brochure to ensure that all informed consent requirements are followed. IQVIA or Sponsor will ensure that all required reviews and approvals by applicable regulatory authorities and ECs are obtained. Zkoušející je odpovědný za provedení Studie ve Zdravotnickém zařízení. Konkrétně pak jde zejména, ale nejen o povinnost Zkoušejícího zkontrolovat a porozumět informacím obsaženým v Souboru informací pro zkoušejícího a zajistit dodržování všech požadavků týkajících se informovaného souhlasu. IQVIA nebo Zadavatel zajistí, že budou opatřena veškerá požadovaná kontrolní schválení od příslušných regulatorních úřadů a EK. Investigator agrees to provide a written declaration revealing Investigator’s possible economic or other interests, if any, in connection with the conduct of the Study or the Investigational Product, or the Sponsor. Zkoušející souhlasí, že poskytne písemné prohlášení vztahující se k potenciálním zájmům Zkoušejícího ekonomické či jiné povahy, či odhalí jiné zájmy, je-li jich, a to v souvislosti s prováděním této Studie či ve vztahu k Hodnocenému léčivu i ve vztahu k Zadavateli. Investigator agrees to provide a written declaration revealing Investigator’s disclosure obligations, if any, with the Institution in connection with the conduct of the Study and the Investigational Product. Zkoušející souhlasí, že poskytne písemné prohlášení, jež bude odhalovat závazky Zkoušejícího, jsou-li nějaké, a to vůči Zdravotnickému zařízení ve vztahu a v souvislosti s prováděním Studie a Hodnoceným léčivem. Investigator is duly licensed to conduct the Study and in good standing. Zkoušející má řádné a platné příslušné oprávnění k provádění Studie. Site agrees to provide prompt advance notice to Sponsor and IQVIA if Investigator will be terminating its employment relationship in the Institution or is otherwise no longer able to perform the Study. The appointment of a new Investigator must have the prior approval of Sponsor and IQVIA. Místo provádění klinického hodnocení souhlasí, že zašle předem promptní oznámení Zadavateli a IQVIA v případě, že Zkoušející ukončí pracovní poměr ve Zdravotnickém zařízení či nebude-li Zkoušející z jakéhokoli jiného důvodu schopen provádět Studii. Ustanovení nového Zkoušejícího bude podléhat předchozímu schválení Zadavatele a IQVIA.

  • moorditj kwabadak Healthy people refers to the commitment we have as an organisation to ensure our staff, patients and the wider community have access to comprehensive healthcare services, in order to maintain healthy lives. Amazing care reflects the sentiment of those consumers accessing our healthcare services from feedback provided to us. This common statement resonates with the health service, and reflects our intentions in our practice and work every day. As a health service which celebrates diversity of culture and languages, it is also important that our vision is shared in the Noongar language. Our Values Our Values reflect the qualities that we demonstrate to each other and our community every day. Our staff make a difference every day to the patients, families and consumers they provide care, advice and support to. The EMHS values capture the shared responsibility that we uphold as most important, which are: • Kindness – kindness is represented in the support that we give to one another. This is how we demonstrate genuine care and compassion to each and every person.

  • SMT XXXXXXXXX XXX, (PAN: XXXXX0000X), wife of Xxx Xxxxxx Xxx, by Nationality Indian, by faith Hindu, by occupation Housewife, residing at Village- Akrampur, PIN-743263, P.O. Akrampur, P.S. Habra, District North 24 Parganas, State West Bengal and (6) SRI XXXXXX XXX, (PAN-XXXXX0000X), son of Xxx Xxxxx Xxxxxx Dey, by Nationality Indian, by faith Hindu, by occupation Service, residing at Village- Akrampur, PIN – 743263, P.O. Akrampur, P.S. Habra, District North 24 Parganas, State West Bengal, hereinafter called and referred to as the VENDORS, all being represented by their Constituted Attorney, XXX XXXXX XXXXXX, (PAN: XXXXX0000X), son of Xxx Xxxxx Xxxxxx, by nationality Indian, by faith Hindu, by occupation Business, residing at BE-111, Sector-I, Salt Lake, Kolkata-700064, Post Office AE Market (Salt Lake City), Police Station Bidhannagar (North), District North 24 Parganas, and being one of the Directors of MAGNOLIA INFRASTRUCTURE DEVELOPMENT LIMITED, (CIN: U70200WB2010PLC152199), (PAN-XXXXX0000X), a Company incorporated under the provisions of the Companies Act, 1956 and having its registered office at 00, Xx. Xxxxxx Xxxxxxx Banerjee Road, Kolkata-700010, Post Office Beliaghata, Police Station: Beliaghata, District South 24 Parganas vide (1) Development Power of Attorney after registration of Development Agreement dated 12th September 2015 registered in the Office of the Additional District Sub-Registrar, Kadambagachi, North 24 Parganas and recorded in Book-I, Volume No. 1519-2015, at Pages 18496 to 18541, being No. 151901639 for the year 2015 and (2) Development Power of Attorney after registration of Development Agreement dated 19th November 2018 registered in the Office of the Additional District Sub-Registrar, Kadambagachi, North 24 Parganas and recorded in Book-I, Volume No. 1519-2015, at Pages 80220 to 80243, being No. 151903193 for the year 2018 (which expression shall unless excluded by or repugnant to the subject or context be deemed to mean and include their respective successors – interest and/or assigns) of the ONE PART. AND MAGNOLIA INFRASTRUCTURE DEVELOPMENT LIMITED, (CIN: U70200WB2010PLC152199), (PAN-XXXXX0000X), a Company incorporated under the provisions of the Companies Act, 1956 and having its registered office at 00, Xx. Xxxxxx Xxxxxxx Banerjee Road, Kolkata -700010, Post Office Beliaghata, Police Station: Beliaghata, District South 24 Parganas, being represented by its Director, XXX XXXXX XXXXXX, (PAN: XXXXX0000X), (AADHAAR NO: 000000000000), son of Xxx Xxxxx Xxxxxx, by nationality Indian, by faith Hindu, by occupation Business, residing at XX-000, Xxxxxx-X, Xxxx Xxxx, Xxxxxxx- 000000, Post Office AE Market (Salt Lake City), Police Station Bidhannagar (North), District North 24 Parganas, hereinafter called and referred to as the “DEVELOPER” (which expression shall unless repugnant to the context or meaning thereof shall include its successors-in-interest and/or permitted assigns of the SECOND PART. AND

  • Xxxxx, Haldimand, Norfolk (a) An employee shall be granted five working days bereavement leave with pay upon the death of the employee’s spouse, child, stepchild, parent, stepparent, legal guardian, grandchild or step-grandchild.

  • Generelt A. Apple Inc. (“Apple”) giver hermed licenstager licens til at bruge Apples software samt tredjeparters software, dokumentation, grænseflader, indhold, skrifter og evt. data, som følger med denne licens, uanset om de forefindes som ROM (Read Only Memory) eller på andet medie (under et kaldet “Apple- software”) i henhold til betingelserne i denne licensaftale. Apple og/eller Apples licensgivere bevarer ejendomsretten til selve Apple-softwaren og forbeholder sig alle de rettigheder, som ikke udtrykkeligt er givet til licenstager.

  • NO HARDSTOP/PASSIVE LICENSE MONITORING Unless an Authorized User is otherwise specifically advised to the contrary in writing at the time of order and prior to purchase, Contractor hereby warrants and represents that the Product and all Upgrades do not and will not contain any computer code that would disable the Product or Upgrades or impair in any way its operation based on the elapsing of a period of time, exceeding an authorized number of copies, advancement to a particular date or other numeral, or other similar self-destruct mechanisms (sometimes referred to as “time bombs,” “time locks,” or “drop dead” devices) or that would permit Contractor to access the Product to cause such disablement or impairment (sometimes referred to as a “trap door” device). Contractor agrees that in the event of a breach or alleged breach of this provision that Authorized User shall not have an adequate remedy at law, including monetary damages, and that Authorized User shall consequently be entitled to seek a temporary restraining order, injunction, or other form of equitable relief against the continuance of such breach, in addition to any and all remedies to which Authorized User shall be entitled.

  • Summer Session A. All ASEs employed in the Summer Session shall receive the same general range adjustment as ASEs received in the preceding Fall term.

  • Povinnosti Site and Institution’s personnel, including Study Staff shall not Místo provádění klinického hodnocení a zaměstnanci Zdravotnického zařízení, a to včetně Studijního personálu, nebudou

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