Ivabradine Sample Clauses

Ivabradine. Ivabradine (IVA) is a novel, specific, heart rate (HR)-lowering agent that acts in sinoatrial node (SAN) cells by selectively inhibiting the pacemaker If current in a dose-dependent manner by slowing the diastolic depolarization slope of SAN cells, and reducing HR at rest and during exercise with minimal effect on myocardial contractility, blood pressure, and intracardiac conduction121. It has been shown to be non-inferior to B-Blockers122 or calcium antagonists123 in HR reduction. Xxxxxxx Xxxxxxxxxx has a role beyond mere heart rate reduction is still a matter of focused scientific research.
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Ivabradine. Ivabradine (Procoralan, Les Laboratories Servier, France; also available under the following names: Coralan, Corlentor, and Coraxan) has been established as an effective treatment to prevent myocardial ischemia in patients with chronic stable angina122, 189, 190, and recent subgroup analysis raised the hypothesis that ivabradine may be helpful to reduce major cardiovascular events26, 191. This constituted the rationale for an ongoing study, Study assess- InG the morbidity–mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIfY), which will assess the effects of ivabradine in terms of CV morbidity and mortality192. It has been found as well, that ivabradine therapy on top of commonly used dosage of B-Blocker therapy had an additional efficacy with no untoward effect on safety or tolerability193. In the recently published results of the SHIFT randomized placebo-controlled study (Iv- abradine and outcomes in chronic heart failure)194, it was found that in patients allocated to ivabradine , the relative risk of the primary end-point (cardiovascular death or hospital admission for worsening heart failure) dropped by 18% compared to placebo, supporting the importance of heart rate reduction with ivabradine for improvement of clinical outcomes in heart failure patients. Pre-clinical animal studies have shown that ivabradine effect might extend beyond heart rate reduction. It was associated with decreased vascular oxidative stress, improved endothelial fuction and reduced atherosclerotic plaque formation195. This has stimulated further research with a planned phase IV RCT, to assess the effect of ivabradine therapy on reducing inflam- matory markers in patients with acute coronary syndromes195, 196.
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Related to Ivabradine

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  • Xxxxx, Haldimand, Norfolk An employee shall be granted five working days bereavement leave with pay upon the death of the employee’s spouse, child, stepchild, parent, stepparent, legal guardian, grandchild or step-grandchild.

  • Generelt A. Apple Inc. (“Apple”) giver hermed licenstager licens til at bruge Apple-softwaren, evt. tredjepartssoftware, dokumentation, , grænseflader, indhold, skrifter og evt. data, som følger med denne licens, uanset om de er præinstalleret på Apple-hardware, forefindes på disk, som ROM (Read Only Memory), på andet medie eller i anden form (under et kaldet “Apple-softwaren”) i henhold til betingelserne i denne licensaftale. Apple og/eller Apples licensgivere bevarer ejendomsretten til selve Apple-softwaren og forbeholder sig alle de rettigheder, som ikke udtrykkeligt er givet til licenstager. B. Apple vil efter eget valg evt. frigive fremtidige opgraderinger eller opdateringer til Apple-softwaren til licenstagers computer fra Apple. Evt. opgraderinger og opdateringer inkluderer ikke nødvendigvis alle de eksisterende softwarefunktioner eller nye funktioner, som Apple frigiver til nyere modeller af computere fra Apple. Licenstagers rettigheder i henhold til denne licens omfatter alle de softwareopgraderinger eller -opdateringer leveret af Apple til Apple-softwareproduktet, medmindre opgraderingerne eller opdateringerne indeholder en separat licens, i hvilket fald licenstager erklærer sig indforstået med, at betingelserne i den licens er gældende for sådanne opgraderinger eller opdateringer.

  • NO HARDSTOP/PASSIVE LICENSE MONITORING Unless an Authorized User is otherwise specifically advised to the contrary in writing at the time of order and prior to purchase, Contractor hereby warrants and represents that the Product and all Upgrades do not and will not contain any computer code that would disable the Product or Upgrades or impair in any way its operation based on the elapsing of a period of time, exceeding an authorized number of copies, advancement to a particular date or other numeral, or other similar self-destruct mechanisms (sometimes referred to as “time bombs,” “time locks,” or “drop dead” devices) or that would permit Contractor to access the Product to cause such disablement or impairment (sometimes referred to as a “trap door” device). Contractor agrees that in the event of a breach or alleged breach of this provision that Authorized User shall not have an adequate remedy at law, including monetary damages, and that Authorized User shall consequently be entitled to seek a temporary restraining order, injunction, or other form of equitable relief against the continuance of such breach, in addition to any and all remedies to which Authorized User shall be entitled.

  • Summer Session A. All ASEs employed in the Summer Session shall receive the same general range adjustment as ASEs received in the preceding Fall term. B. The following articles apply to ASEs who are employed in the summer session: Recognition, Wages (range adjustment only), DCP, Travel, Health and Safety, Leaves, Holidays, Duration, Workspace and Instructional Support, Parking, Grievance and Arbitration, Waiver, Management and Academic Rights, No Strikes, Non-Discrimination, Union Access and Rights, Union Security, Discipline and Dismissal, Emergency Layoff, Employment Files and Evaluations, Definitions, Severability, Labor-Management Meetings, and Classifications. C. The remainder of the articles in the agreement does not apply to ASEs who are employed in the summer session. D. The topic of Summer Session, and effects of changes on terms and conditions of employment for ASEs employed in Summer Session, shall be reopened for bargaining commencing no later than January 2, 2001.

  • Povinnosti Site and Institution’s personnel, including Study Staff shall not Místo provádění klinického hodnocení a zaměstnanci Zdravotnického zařízení, a to včetně Studijního personálu, nebudou

  • COVID-19 Vaccine Passports Pursuant to Texas Health and Safety Code, Section 161.0085(c), Contractor certifies that it does not require its customers to provide any documentation certifying the customer’s COVID-19 vaccination or post-transmission recovery on entry to, to gain access to, or to receive service from the Contractor’s business. Contractor acknowledges that such a vaccine or recovery requirement would make Contractor ineligible for a state-funded contract.

  • Xxxxxx and Recall 1. When the Board determines to reduce the number of positions in one or more classifications covered by this agreement because of decreased enrollment of pupils, suspension of schools, territorial changes, lack of work, return to duty of an employee from a leave of absence, or financial reasons, the Board shall follow the procedure set forth in this Section. 2. The Board shall determine in which classification the layoffs should occur and the number of employees to be laid off. 3. The Board shall lay off employees in the affected classification on the basis of reverse seniority in that classification. Seniority shall be defined as the length of continuous service as a regular employee of the Board of Education. 4. The names of laid off employees shall be kept on a recall list by classification until for two years maximum. If the Board determines to fill any position in a classification during this period of time, the Board must offer the position to the most senior employee on the recall list for that classification. The offer of recall shall be made by written notice sent to the employee at his most recent address on record by certified mail. It is the employee's responsibility to keep the Board informed of his up to date address. The employee shall have seven (7) days after the notice is mailed to accept the offer of recall and report to work. If he does not report during such seven-day period, his name shall be eliminated from the recall list and the employment relationship between him and the Board shall cease. If the first employee on the recall list for a classification does not accept the recall, the Board shall offer the position to the next most senior employee from that classification on the recall list by the procedure outlined in this Section, and so on, until the position is filled. Any employee who resigns after receiving the notice provided in Division 4 of this Section, shall be entitled, upon request, to be placed upon the recall list and shall have same recall rights as if laid off. 5. For purposes of this Section, the following classifications will be used. 1. Bus Driver 9. Bus Aide 2. Bus Mechanic 10. Head Cook 3. Building Maintenance 11. Cafeteria Worker

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