Mass Spectrometric Methods for Protein Ex Sample Clauses

Mass Spectrometric Methods for Protein Ex pression Profiling Accurate quantification of proteins of different samples, such as diseased vs. healthy tissue, plays a vital role in proteomics. This quantification can be either absolute or relative. Absolute quantification involves the determination of the exact quantity of a protein (peptide) in a given sample. Relative quantification involves estimating the quantity of a protein (peptide) in relation to the quantity of the same protein (peptide) in a different sample, or the same sample in an altered state. The absolute signal intensity of a peptide ion does not always reflect the true abundance of the peptide in the analyzed sample. This is due to differences in ion- ization efficiency, ion suppression, and the inconsistency in the detection of analytes across different MS runs. However, differences in the relative peak intensities of the same analyte do accurately reflect differences in its expression. Various methodolo- xxxx have been developed to quantify relative changes in protein abundance between samples. These methods fall broadly into two categories: label-free methods, and methods based on stable isotope labeling. In this work, we focus exclusively on the latter category.
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