Microtablets Sample Clauses

Microtablets. Microtablets with diameters of 0.5-3mm containing permeation enhancers and/or enzyme inhibitors were designed and investigated for the peroral delivery of protein and peptide drugs. The permeation enhancers must be released rapidly from the dosage form and prior to the release of the peptide over a wide area across the epithelium. In order for the peptide to pass through the epithelium, the site of opening of the paracellular pathway must coincide with the site where the peptide is released from the dosage form [45]. Hence, multiple unit dosage forms (MUDFs) were designed to control the release of the drug [46, 47]. The minitablets can be then filled in gelatin capsules and enteric coated to be protected from the acidic condition of the stomach. Microtablets are easy to manufacture, can be used in defined sizes and strengths and show low variability within a batch [48]. In a study by Xxx xxx Xxxxx et al. minitablets containing TMC permeation enhancer and Desmopressin (1-(3-mercaptopropionic acid)-8-D-arginine Vasopressin monoacetate (DDAVP) were designed. The release of both DDAVP and TMC from different formulations of multi tablets was investigated [45]. The results suggested that suitable DDAVP release was obtained only from formulations that were too big to be fit inside the largest available gelatin capsule rendering them unsuitable for in vivo usage.
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