OpenBF Sample Clauses

OpenBF. OpenBF is a whole-circulation 1D cardiovascular model that describes the physics of pulse wave propagation throughout the main vessels of the arterial system, including the Circle of Xxxxxx. The model has been previously quantitatively validated with predictions from other models and experimental data. In a recently published study driven by our clinical end-users and collaborators [18, 19, 20] we have used the code to identify more effective biomarkers of a cardiovascular condition affecting patients after stroke (cerebral vasospasm), and more recently have started developing the code towards clinical utility as a computational platform to explore what-if clinical scenarios to support clinical decision in treatment of ischaemic stroke and mechanical removal of blood clots. End-user solution type Please tick one or more Non-clinical research ✔ Clinical research ✔ Clinical decision support ✔ Drug discovery Design & optimisation In silico preclinical trials In silico clinical trials Personal health forecasting ✔ Provider: USFD Contact email: x.xxxxx@xxxxxxxxx.xx.xx Number of user organisations (list the top 5): USFD, University Hospital of Tours, Federal University of ABC (Xxxxx Xxxxx’, Brazil) Estimated users at M0: 1 Estimated users at M24: 6 Estimated users at M36: 6 Access mode: Source URL: xxxxx://XXXXXXXX.xxxxxx.xx/openBF User manual: xxxxx://xxxxxxxx.xxxxxx.xx/openBF/Docs/index.html HPC Systems: ShARC (USFD), HPC Cloud (SURFsara) HPC motivation: Uncertainty quantification; sensitivity analysis; embarrassingly parallel simulation Additional user information: End user name Alessandro Xxxxx Xxx Xxxxx Narata’s group Xxxxx Xxxxxxx Affiliation Vivacity Labs, London, UK University Hospital of Tours, France USFD Application area Transportation and machine learning Diagnosis of cerebral vasospasm, management of ischaemic stroke Treatment of ischaemic stroke No. of associated users 1 3 2 Target use Commercial Clinical Research / clinical Improvements implemented openBF formed the theoretical basis for the development of a model aimed at a more effective management of traffic at national level in the UK The code was extended to allow simulation of blood clot removal and the influence of the medical device used for this treatment on blood flow Code was further developed to allow prediction of influence of the medical device used in procedure (thrombectomy) on haemodynamics and the blood clot being removed. Impact N/A Papers [19, 21] and conference presentations1 ...

OpenBF. OpenBF is a numerical model that simulates the physics of pressure and flow-rate waves propagation across the elastic vessels of a typical arterial network. The model predicts pressure and volumetric flow values along the cardiac cycle (waveforms) at several locations along each vessel of a network that currently includes 78 arteries of the systemic and cerebral circulation. This Navier-Xxxxxx-based 1D model5 is fully validated, and its numerical predictions are computed by means of the MUSCL explicit finite volume scheme. OpenBF is written in Xxxxx and it has been released as open-source under a LGPL-2.1 license (xxxxx://xxxxxx.xxx/INSIGNEO/openBF). The code is well documented and supported by installation guidelines and tutorials to ultimately maximise end-users’ uptake. As the current openBF implementation is serial and does not exploit multi-core architectures, within CompBioMed, the code has been deployed and tested on the SURFsara cloud system. In this environment, OpenBF will be used to populate a database of waveform datasets to be used as boundary conditions by the higher-dimensionality cardiovascular models in the consortium. The waveforms contained in the database will be calculated by means of Monte Carlo analysis over typical physiological ranges for all the model parameters. The resulting database, which will be made available through the CompBioMed Centre of Excellence, will be annotated and filtered to retain only realistic waveforms towards the development of a database representing a virtual population. Future developments of OpenBF includes extension of the code that will allow strong-coupling to higher-dimensionality codes, and the exploration and testing of clinically-relevant hypotheses where cardiovascular disease might influence waveforms, and inform future development of diagnostic technologies.