Primary Biliary Cirrhosis Sample Clauses

Primary Biliary Cirrhosis. Primary Biliary Cirrhosis (PBC) is an autoimmune liver disease that generally effects middle aged women. (157) It is characterised by a chronic inflammatory destruction of the interlobular and septal bile ducts that results in chronic cholestasis and biliary cirrhosis and portal hypertension. It is an autoimmune disorder characterised by highly specific autoantibodies, activated T cells in areas of bile duct destruction and association with autoimmune disorders. (157) The disease had predominance for women with a female to male ratio of 9:1 and a median range of onset of 50-years. Information regarding pregnancy in women with PBC is rare, as PBC is a condition that typically has been described to effecting middle aged women and furthermore, historically women with pruritus were advised against pregnancy. Over the last decade several normal deliveries have been reported in women with PBC without an obvious effect on the underlying liver disease. (158-161) Xxxxxx et al described 9 pregnancies in 6 patients with PBC, in which there were no foetal losses, a median gestation of 37 weeks and all infants healthy at 4 years follow-up. (160) Maternal outcomes were also favourable, with all mothers remaining asymptomatic throughout pregnancy. Interestingly, in contrast to case series reported in women with PSC, (155) in this small series cholestatic parameters and mitochondrial antibody titres fell in all women during the gestational period. (160) However in the first three months postpartum, cholestatic parameters deteriorated in all cases but subsequently returned to preconception values. (160) A recent publication has confirmed the above findings, reporting a favourable safety profile in pregnant women with PBC with a tendency to a post-partum flare in cholestatic parameters. (162)
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