Principal Findings Sample Clauses

Principal Findings. While the 2h-OGTT is the standard to identify diabetes with maximum sensitivity and specificity, it is inconvenient and time-consuming and hence may not be suitable for screening, in particular opportunistic screening in primary care. Currently, there is no consensus as to which screening strategy is best for detecting individuals with high-risk prediabetes or diabetes in the general population. This analysis demonstrated a suitable screening strategy using a glucose challenge test first followed by fasting plasma glucose. An AROC of 0.85 and 0.96 to detect high-risk prediabetes and the standard diabetes status (2h-OGTT>199 or FPG>125) respectively resulted from this study. However, with the other two outcomes (2h-OGTT > 199 mg/dl or A1c ≥ 6.5% and 2h-OGTT > 199 mg/dl or A1c ≥ 6.5% or FPG > 125), different paired tests were revealed as the highest area under the curve. Paired tests in these two outcomes became harder to distinguish while FPG + GCT was clearly superior in the first two diabetes definitions. Fairly consistent results were obtained from all four outcomes. Regardless of the diabetes definition, 2h-OGTT had the highest AROC analyzing all subjects, followed by FPG and GCT. However, in the outcome combing glucose and A1c measurements (2h-OGTT > 199 or A1c ≥ 6.5%), A1c was ranked higher than FPG but was not found significantly different from FPG or GCT. In general for the outcomes, 2h-OGTT performed the best against the other single tests. Only in the two categories defined as 2h-OGTT >199 or FPG > 125 and 2h-OGTT > 199 or A1c ≥ 6.5% or FPG > 125 was the “gold standard” test not significantly different when compared to FPG. Further, there was no difference between FPG and GCT in any of the outcomes. Based on predictive accuracy, 2h-OGTT and FPG were the two strongest tests. These two tests are currently endorsed by the ADA as diagnostic tools for both diabetes and high-risk prediabetes. [13] RPG and A1c, routinely the lowest AROCs, were no different when compared in all but one diabetes status. Review of A1c Generally, A1c had one of the lowest areas under the curve when analyzing all patients. The performance of other tests was not improved by pairing them with A1c since all paired tests that included A1c were not statistically different when compared to FPG, RPG, or GCT. But when comparing these paired tests to A1c, all were found to have a significantly higher area under the curve. Xxxxxxxxxxxxx, X0x has been recently recommended by the ADA as ...

Principal Findings. This is the first incidence study carried out in Italy on prospectively identified and evaluated individuals with a FEP. We found an overall incidence rate of psychosis of 16.4 per 100,000. Other psychosis-incidence studies already available in Italy are based on case-registers or data concerning admission to general psychiatric hospitals (Xxxxxxxxxxx et al., 1993; Xxxxx et al., 2000). Interestingly, our finding of an overall schizophrenia IR of 7.3 per 100,000 is very similar to the mean rate of first admission to general hospital psychiatric services for schizophrenia found by Xxxxx et al (2000). We also found an increased incidence of psychosis in young people, men and MI, after adjusting for gender and age. In particular, the incidence of psychosis was more than three times the overall rate in those aged 18-25 years (54.6 per 100,000).