Rational Sample Clauses

Rational a) All properties are susceptible to spills whether it is a result of operations or by customers. Insufficient response, inadequate containment materials and improper spill cleanup methods will result in pollutants in our waterways. Once the pollutants reach our storm drain system, or even the detention pond, they are difficult and expensive to remove.
Sample 1
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Rational. The premium (Prospective, Randomized Investigation to Evaluate Incidence of Headache Reduction in Subjects With Migraine and PFO Using the AMPLATZER PFO Occluder to Medical Management) study hypothesis was based on the possible significant reduction in the frequency of migraine attacks with and without aura after percutaneous correction of PFO and broad dx-sin shunt in patients symptomatic for migraine from 6 to 14 days/month and not responsive to drug therapies. The primary endpoint of the studywas to reduce the frequency of migraine attacks (with or without aura) by at least 50%; the proportion of patients with headache reduction was superimposable in the PFO correction group (38.5%) and in that addressed to medical therapy (32%), p=0.32. With regard to secondary endpoints, there was a significant reduction in the number of migraine days/month after CORRECTION of PFO compared to the control group (: –3.4 ±4.4 days versus –2.0 ±5.0 days (p = 0.025). No difference was observed in the percentage of patients who achieved a 75% reduction > migraine attacks while a very significant difference was observed with regard to subjects who experienced a complete regression of migraine episodes: 8.5% (10/117) in the PFO correction group vs 1.0% (1/103) in the medical therapy group (p=0.01). Among these patient responders, 6 were symptomatic for migraine with aura while the other 4 were migraines with isolated episodes of aura. It could be speculated that the etiological mechanism of headache in patients not subjected to PFO closure could be the activation of platelets inside the tunnel, the overlap between septum primum and secundum, of the patent foramen ovale. This segment, which may be characterized by a potential flow turbulence between the two septa, could lead to platelet activation, especially in the presence of SIA aneurysm. In a small group of patients with migraine, resistance to aspirin has been documented in 24% of subjects, suggesting platelet hyper-reactivity. Clopidogrel and aspirin are more effective than aspirin alone in reducing headache, exacerbated after percutaneous correction of PFO in the first follow-up period24 to demonstrate that platelet microaggregates may be responsible for post-closure migraine of PFO and may play a central role in the genesis of headache. In women and patients with stable coronary artery disease, in antiplatelet therapy with aspirin, high platelet reactivity (HAPR) or resistance to aspirin has been described and is assoc...
Sample 1
Rational 
Sample 1

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