Clinical implications. The current study emphasizes that vasoplegia is a severe clinical condition which occurs frequently after SVR. In particular, the increased mortality and the negative effect on renal function should be taken into account when considering SVR. On the other hand, NYHA class and cardiac function improved in both vasoplegic and non-vasoplegic patients, underlining the benefits of surgery for both groups. Accordingly, the development of strategies preventing vasoplegia are an important clinical need. Until preventive measures become available, patients could potentially benefit from preoperative hemodynamic optimization, early-onset and aggressive treatment of vasoplegia and perioperative renoprotection strategies.
Clinical implications. The findings summarised in the current systematic review have important clinical implications. Firstly, they highlight the relevance and role of social rank in the EDs field. This adds to the growing interest in the role of interpersonal difficulties in the aetiology, maintenance and treatment of EDs, suggesting the importance of considering social rank and the related cognitive, affective and interpersonal correlates of it. Most of the studies included in the current review are cross-sectional, therefore, there is lack of definitive evidence about causation. However, interpersonal difficulties could be a trait-vulnerability factor for EDs and could be considered at the heart of ED symptomatology, with the function of restoring or maintaining social rank, as well as coping with the difficult emotions arising from perceiving oneself as low social rank and generate a sense of achievement. Importantly, the current review has highlighted that social rank is relevant to all the different types of EDs. Therefore, this could set the ground for developing transdiagnostic approaches and treatments, which could be applied to all EDs in a cost-effective manner (Xxxxxx, Xxxxxxxx & Xxxxx- Xxxxxxx, 2016). Given this role of social rank, interpersonal treatments for ED aimed at reducing eating disorder pathology by improving interpersonal functioning could be important. The current findings may inform existing therapies such as Interpersonal Psychotherapy for EDs (Xxxxxx et al., 2010) and Cognitive Behaviour Therapy for EDs (CBT-E; Xxxxxxxx, 2008) in supporting individuals challenging negative automatic thoughts associated with social rank as well as finding alternative contexts in which to achieve status (Xx Xxxxx et al., 2017; Xxxxx et al., 2014). Supporting individuals finding personal qualities and skills as well as successful areas of their lives that go beyond the ED could be helpful to improve their rank perception and challenge the role of the ED. This should go alongside a recognition of the potential contribution of environmental factors, such as childhood experiences or traumatic experiences, in the development of low social rank mentality and maintenance of the disorder. Additionally, improving individuals’ ability to be more assertive and dominant in interpersonal relationship may also be very important (Xxxxxxxxx et al., 2012; Brugnera et al., 2018). An assertive interpersonal style is at the heart of positive and healthy interpersonal relationship and to m...
Clinical implications. The administration of PROMs to capture personal perceptions of activity limitations and participation restrictions following impairment is central in guiding clinical goal setting and assessing outcomes that are valued by the individual. However, accurate interpretation of PROM measures is crucial to ensure proper goal setting and outcome measurement. Results of the present study suggest that scores supplied by informants and PWA are not consistently interchangeable, and like previous studies, informants are more likely to rate PWA more negatively than PWA rate themselves. Results of this study also suggest that informants may rate PWA more positively on constructs relating to social roles than PWA themselves. Clinicians must be aware of the unobservable constructs that may guide an individual’s attitude towards their own participation and activity restrictions but may evade informant recognition according to our findings. Results of the present study may indicate a greater need for speech language pathologists to provide greater aphasia education and communication skills training to caregivers. Providing caregivers with a better understanding of the concomitant psychosocial effects aphasia may have on their loved ones, as well as the less salient components of language as reported by Xxxxxxxx and Xxxxx (2015) could help bridge the discrepancies between perspectives on measures of quality of life. The present research provides evidence that PWA with less severe language deficits are likely to perceive themselves as having worse activity limitations and participation restrictions than individuals with more severe language deficits. Clinically, it is critical to ensure that patients have adequate emotional support to navigate the new normality of living with aphasia. The implementation of psychosocial support to bolster emotional support and redirect negative images of self may be warranted for these individuals with aphasia. Xxxxxxxxx and colleagues (2018) operationalized psychosocial support to help manage negative reactions through counseling and address the participation and activity consequences associated with aphasia. Through implementation of interventions targeting psychosocial support, individuals across all aphasia severities may learn to accept their new normality and perceive one’s capabilities and functioning through a more positive lens. However, the implementation of psychosocial interventions for people with aphasia presents with numerous ba...
Clinical implications. The present findings add to the growing body of evidence (Xxxxxxxxx et al., 2009; Xxxxxxxxxx et al., 2008; Xxxxxxxx & Xxxxxx, 2006; Xxxxx & Xxxxxxxx, 2007) that mindfulness can be used in the treatment of current depression, and may be a valuable therapeutic intervention in the amelioration of symptoms. Mindfulness has been used as a clinical intervention as part of the full MBCT programme, which was initially indicated only for remitted depressed patients with a history of 3 or more previous depressive episodes. The current study suggests that mindfulness can also be effective as an intervention in itself (i.e., not as part of the MBCT programme), and that it has beneficial effects for a broader range of depression presentations (i.e., not just patients in remission). The study showed that brief mindfulness and relaxation interventions led to the amelioration of depressive symptoms. Therefore, the provision of such interventions whilst patients are on the waitlist to receive psychological therapy could become available within relevant NHS services. In the current study, patients had two face-to-face sessions (although only one was an intervention session), but most of their practice was done on their own, thus the interventions were predominantly self-help with the use of audio recording. In clinical services, these interventions could potentially be provided through online therapy (e-therapy) and self-help. E-therapy and self-help have become important resources, and have shown high rates of patients’ and clinicians’ satisfaction (Xxxxx et al., 2000), as well as symptom reduction (Xxxxxxxx et al., 2010). In addition to potential patient benefit, provision of such interventions would likely be cost-effective. Considering that the ability to decenter predicted changes in depressive symptoms during the active stage of treatment, clinical interventions for depression may incorporate a specific focus on improving decentering skills (for example, by emphasising letting go of negative thoughts and feelings) through mindfulness training (as in the current study), or other therapeutic interventions (such as CBT). The findings of the study showed that both mindfulness and relaxation had comparable amount of change in self-compassion. Emerging theory on self- compassion (e.g., Xxxxxxx, 2009) suggests that compassion is adaptive in the face of negative thoughts and feelings, and thus plays an important role in symptom change. Moreover, depressed patients seem to hav...
Clinical implications. In terms of the clinical relevance of these data, a large effect was observed for reduced ratings of unpleasantness for normatively negative stimuli in participants with meditation experience. Perceiving stimuli as unpleasant or aversive is a key process in both anxiety and depression, and if emotional experience is appraised as less aversive then it is less likely to lead to experiential avoidance (Xxxx, 2007; Xxxxxxxx et al., 2009), a transdiagnostic process involved in the maintenance of several psychological conditions (Xxxx, 2007). A medium sized effect was observed for group differences in arousal and SCR. For positive stimuli, differences were observed in both self-reported arousal and physiological responding, and these data suggest less engagement with potentially rewarding stimuli in those with meditation experience. These data may be of relevance to psychological conditions wherein the reward system is emphasised such as addictions, and it is of note that mindfulness-based interventions have had some success in this area (Xxxxxxxx et al., 2009). For negative stimuli, no differences were observed on a physiological level, but self- reported arousal was reduced in meditators. These data suggest differences at the level of cognitive appraisal and perceived arousal when responding to negative stimuli. Both reduced physiological arousal in the case of positive stimuli, and perceived arousal in the case of negative stimuli are likely to confer advantages in terms of wellbeing, and are consistent with an account that emphasises contentment as a means of affect regulation (Xxxxxxx, 2009). Overall these data fit with transdiagnostic conceptualisations of mental health. Mindfulness-based approaches also emphasise self-regulation, and so self-efficacy, with few reported side effects (Xxxxxx, Xxxxxx, & Xxxx, 2012). However, a related issue is the usefulness of these approaches for different service users. Mindfulness-based approaches have been shown to reduce mental distress in many different psychological and physical health conditions, which could be viewed as a lack of specificity. It is likely to be of most use in targeting transdiagnostic processes with a theoretical basis such as overengagement with mental contents through processes such as rumination, and/or experiential avoidance (Xxxx, 2007). That said, mindfulness practice is not always easy and requires an ongoing commitment which is a further consideration when assessing suitability for mindfuln...
Clinical implications. Physical activity (PA), health and quality of life are closely interconnected: the human body is designed to move and therefore needs regular PA in order to function optimally and avoid illness. Regular PA can increase general wellbeing, improve psychological and physical health, help to maintain self-sufficiency, and prevent specific metabolic disorders, such as type 2 diabetes, metabolic syndrome, and hypercholesterolemia. On the contrary, it has been observed in literature [1] [2] that a sedentary lifestyle is a risk factor for the development of many chronic illnesses. The psychological discomfort linked with aging can be modified or minimized by engaging in pleasant and shared PA. Sedentary people who become more physically active report feeling better from both a physical and a mental point of view, and enjoy a better quality of life. Based on the epidemiological studies carried out in Europe, it is evident that those who would highly benefit from regular physical activity (e.g., adults over 65 years of age) are generally the most sedentary [4]. For this purpose, the implementation of a European wide policy to improve active living and prevent physical and mental diseases is strongly needed. More specifically, methodologies and technologies which aim to make physical activity easier and promote personal responsibility in individuals aged over 65 years are warranted [3]. For adults aged over 65 years, the same goals as for healthy younger adults should be achieved with additional exercises like strength training and balance exercises to prevent falls. These are in addition to the routine daily activities (e.g., cleaning rooms, walking to go shopping, climbing stairs)[6]. PA, which causes a noticeable increase in heart rate, is beneficial for disease prevention. Some studies show that walking briskly for even one to two hours a week (15 to 20 minutes a day) starts to decrease the chances of having a heart attack or stroke, developing diabetes, or dying prematurely [7]. Walking is an ideal exercise for many people—it does not require any special equipment, can be done any time, any place, and is generally very safe. Several studies [8] [9] [10] [11] [12] [13] have demonstrated that this simple form of exercise substantially reduces the chances of developing heart disease, stroke, and diabetes in different populations. To obtain significant effects of physical activity interventions in the elderly, the typical dose of physical activity prescribed is 20–6...
Clinical implications. The young offender population under investigation showed high levels of childhood adversity, as measured by the ACEs, and a greater propensity to respond to hypothetical ambiguous scenarios that had the potential to elicit distress, with negative intent. In line with previous research (x.x. xxx Xxxxxxxxxx, Xxxxxxxxx & Xxxxxxxx-Xxxxxxxxxx, 1999; Xxxxxx et al., 2000) this is suggestive of individuals with avoidant attachment patterns. Within the current study ACEs also correlated with attachment avoidance, as measured by the XXX (Xxxxx et al., 2006) and as such does not suggest there is added value of using the simulation task within this population as a measurement of working models of attachment. However, the literature suggests that those who have an avoidant attachment style have been shown to use deactivating strategies such as suppression (x.x. Xxxxxxxxxx et al., 2002) and regulate attachment by diverting attention away from attachment-related issues (x.x. Xxxxxx et al., 2001). When interviewed, avoidant individuals have also been shown to dismiss attachment experiences as unimportant and unperturbing (Xxxxx, 1999). Furthermore, avoidant clients have been rated by treatment providers as seeming less committed and engaged (Xxxxxx, 1990; Xxxxxxxxxx et al., 1997). Therefore, as has been suggested by researchers within other disciplines (e.g. probationary services: Xxxxxx, 2008; psychosis: Xxxxxx et al., 2014) an attachment framework may be useful in considering how to engage and adapt interventions to best meet the needs of a young offender population. For instance, although not exclusive to their approach and based on their experience of working with adult sexual offenders, Xxxx and Xxxxxxxx (2011) have put forward an attachment-based model to working with adults who present with insecure attachment styles. This approach suggests that exploring relational dynamics and patterns of interaction within the therapeutic relationship can improve outcomes when working with individuals who may otherwise be seen to be resistant to therapeutic change (Xxxxxx & Xxxxxx, 2014). From the researchers own experience, there are many skilled professionals working with young offenders across the varying disciplines (e.g. probation, prison staff, mental health and forensic practitioners). However, with an emphasis on evidence-based approaches being applied across prison settings (Xxxxxxxx & Xxxxxxx 2012) and services working directly with offenders (e.g. social work/probatio...
Clinical implications. The findings from the review support the inclusion of social factors in explanatory models both as causal and maintaining features (Xxxxxxx & Treasure, 2006; Treasure et al., 2012; Treasure & Xxxxxxx, 2013). The mechanism by which these problems contribute to the maintenance of the disorder remains unclear. Interventions which target problematic aspects of social processing may be of particular benefit or enhance existing treatments. For instance oxytocin might be used to improve the therapeutic alliance in forms of ED in which this social processing system is perturbed (Xxxxx-Xxxxxxxxxx, Domes, Kirsch, & Xxxxxxxxx, 2011). There is potential to improve the functioning of these circuits by using forms of brain training to encourage plastic changes in these circuits, such as attentional bias modification (Renwick, Campbell, & Xxxxxxx, 2013). It is important to involve partners (Bulik, Baucom, Kirby, & Pisetsky, 2011) and families (Xxxxxxx et al., 2011) in the treatment of ED.
Clinical implications. It is unlikely that variation between expected and observed differences in FEV1 and FVC could account for the lack of a difference between segmentectomy and lobectomy in the two large clinical trials [JCOG 0802 (1) and CALGB 140503 (2)]. This is because the degree of error would be expected to be the same on both sides of the randomisation arms. The more likely explanation would be that the amount of lung tissue resected in the sublobar arms would be similar to “lobectomy” to achieve cancer clearance as the 2 cm lesions do not usually sit nicely within the centre of one segment or peripherally to allow a wedge with minimal tissue clearance (as expected when the trials were designed). Journal of Thoracic Disease, Vol 16, No 1 January 2024 251 Also, the concept of a lobectomy is often misinterpreted as a larger resection given left upper division segmentectomy is the same amount of tissue as right upper lobectomy and left lingula segmentectomy is the same amount of tissue as a right middle lobectomy. Our results suggest that when consenting patients in clinic prior to lung resection, it is no longer accurate to simply estimate the amount of lung tissue loss if FEV1 is used as a yardstick measure, as it overestimates postoperative losses, and prohibits patients proceeding to surgery or alters the extent of resection recommended on inaccurate measures (12). Future clinical guidelines also need to be aware of our findings to allow for better recommendations for both surgeons and patients. For example, the use of 40% postoperative predicted value is often used as a yardstick for patient selection for lung resection (12) and our results suggest that on average the actual values are expected to be approximately 10% higher.
Clinical implications
